Treatment of HeLa cells with tumour necrosis factor alpha (TNFalpha) induced caspase processing of ectopic PKC (protein kinase C) zeta, which converted most of the holoenzyme into the freed kinase domain and increased immune-complex kinase activity. The goal of the present study was to determine the basis for the increased kinase activity that is associated with caspase processing of PKC zeta. ...

In simulating continuum model fluids that undergo phase separation and criticality, significant gains in computational efficiency may be had by confining the particles to the sites of a lattice of sufficiently fine spacing, a(0) (relative to the particle size, say a). But a cardinal question, investigated here, then arises; namely, How does the choice of the lattice discretization parameter, ze...

The electrical potentials at membrane surfaces (psi0) strongly influence the physiological responses to ions. Ion activities at membrane surfaces may be computed from psi0, and physiological responses to ions are better interpreted with surface activities than with bulk-phase activities. psi0 influences the gating of ion channels and the driving force for ion fluxes across membranes. psi0 may b...

Consider a $2$-nondegenerate constant Levi rank $1$ rigid $\mathscr{C}^{\omega}$ hypersurface $M^5 \subset \mathbb{C}^3$ in coordinates $(z, \zeta, w = u+iv)$: \[ u F(z,\zeta,\overline{z},\overline{\zeta}). \] The Gaussier-Merker model $u \frac{z \overline{z} + \frac{1}{2} z^2 \overline{\zeta} \overline{z}^2 \zeta}{1 - \zeta \overline{\zeta}}$ was shown by Fels-Kaup 2007 to be locally CR-equiva...

We investigate the effects of image charges, interfacial charge discreteness, and surface roughness on spherical electric double layer structures in electrolyte solutions with divalent counterions in the setting of the primitive model. By using Monte Carlo simulations and the image charge method, the zeta potential profile and the integrated charge distribution function are computed for varying...

BACKGROUND Whereas the presence of a lymphoid infiltrate has been associated with a favourable prognosis in colorectal carcinoma, the proliferative and cytotoxic responses of freshly isolated tumour infiltrating lymphocytes are frequently impaired. In mice, tumour induced immune suppression has been associated with a decreased expression of the zeta-chain of the T cell receptor (TCR)-CD3 comple...

We give an explicit formula for the local normal zeta functions of torsion-free, class-2-nilpotent groups at primes p where the associated Pfaffian hypersurface has good reduction mod p and contains no lines. We show how together the functional equations of two types of zeta functions the Weil zeta function associated to an algebraic variety and zeta functions of algebraic groups introduced by ...

CD43 is an abundant cell surface sialoglycoprotein implicated in hemopoietic cell adhesion and activation. Cell stimulation through CD43 results in recruitment of different signaling proteins, including members of the Src family kinases, Syk, phospholipase Cgamma2, the adapter protein Shc, the guanine nucleotide exchange factor Vav, and activation of protein kinase C. In this study, we report t...

Zeta potential is the key parameter that controls electrostatic interactions in particle dispersions. Laser Doppler electrophoresis is an accepted method for the measurement of particle electrophoretic mobility and hence zeta potential of dispersions of colloidal size materials. Traditionally, samples measured by this technique have to be optically transparent. Therefore, depending upon the siz...