Dear Sir: In a recent article, Edupuganti and others reported a clinical study of co-administration of subcutaneous yellow fever (YF) 17D vaccine (YF-VAX Ò ; Sanofi Pasteur, Lyon, France) and intramuscular immune serum globulin (ISG) (amaSTAN S/D Ò ; Talecris Biotherapeutics, Research Triangle Park, NC) or saline placebo. 1 The study was designed to test whether co-administration of vaccine and...

Years before the emergence of infamous Cuban revolutionaries like Castro and Guevara, a Cuban physician by the name Carlos Juan Finlay was stirring up a revolution of his own. The son of a Scottish physician, Finlay was born and raised in Havana, and educated in France, England and the United States. Described as courteous and energetic with boundless capacity for work, Finlay was first and for...

Flaviviruses are responsible for yellow fever, Zika fever and dengue, all of which are major human diseases found in tropical regions of the globe. They are zoonoses with a transmission cycle that involves primates as reservoirs and mosquitoes of the genus Aedes as vectors. The recent upsurge of urban epidemics of yellow fever, Zika fever and dengue has involved human-to-human transmission with...

Sera collected in May 1984 from 132 adult residents of Karamoja district, Uganda, were examined by haemagglutination inhibition tests for antibodies against selected arboviruses, namely Chikungunya and Semliki Forest alphaviruses (Togaviridae); dengue type 2, Wesselsbron, West Nile, yellow fever and Zika flaviviruses (Flaviviridae); Bunyamwera, Ilesha and Tahyna bunyaviruses (Bunyaviridae); and...

The World Health Organization (WHO) and its partners despatched 1.9 million doses of yellow fever vaccine to Angola last month to quell a large outbreak, amid fears it could spread to other parts of central and eastern Africa. Since the outbreak was first reported in the capital Luanda in December 2015, it has spread to at least five of the country’s 18 provinces. As of 10 April, 582 people wer...

Yellow Jack is a compelling and thorough narrative of one of the most interesting chapters in medical history. The book, which is highly readable even to those who may think they know this story, is based on a series of articles written by one of the authors, John R. Pierce, for Stripe, a publication of the Walter Reed Army Medical Center. Dr Pierce was a colonel in the Army Medical Corps and r...

Yellow Jack is a compelling and thorough narrative of one of the most interesting chapters in medical history. The book, which is highly readable even to those who may think they know this story, is based on a series of articles written by one of the authors, John R. Pierce, for Stripe, a publication of the Walter Reed Army Medical Center. Dr Pierce was a colonel in the Army Medical Corps and r...

The incidence of enteric (typhoid) fever in travelers is estimated to be approximately 3-30 cases per 100,000 travelers to developing countries. Recently, it is become clear that travelers who are visiting friends and relatives, especially travelers to the Indian subcontinent, seem to be the most vulnerable to enteric fever and require special attention for prevention. Recent concerns are the i...