para-Selective processes for the chlorination of phenols using sulphuryl chloride in presence various sulphur-containing catalysts have been successfully developed. Several chlorinated phenols, especially those derived by para-chlorination phenol, ortho-cresol, meta-cresol, and meta-xylenol, are significant commercial importance, but reactions such not always as regioselective would be desirabl...

Ethyl ester of 5,7-dimethyl coumarin-4-acetic acid has been synthesized from 3,5-Xylenol in a two step sequence of reaction involving Pechmann cyclisation and acid catalyzed esterification. The title compound 2 crystallizes in Monoclinic form, space group P 1 21/c 1, with a = 8.6248(4) Ǻ, b = 18.9103(8) Ǻ, c = 8.4204(4) Ǻ, β = 101.241(2), V = 1347.00(11) Ǻ, D cal = 1.283 Mg/cm3, Z = 4. The mole...

7. Hancock BW, Naysmith A. Hypersensitivity to chlorocresolpreserved heparin. BMJ. 1975;27:746--7. 8. Freitas JP, Brandão FM. Contact urticaria to chlorocresol. Contact Dermatitis. 1986;15:252. 9. Yamano T, Shimizu M, Noda T. Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multipledose guinea pig maximization test. Toxico...

This study investigates the effects of seeding a chondrogenic and osteogenic scaffold with a bone marrow-derived cell concentrate (BMCC) and reports the histological and mechanical properties 3 months after implantation in the miniature pig. Twenty defects (7×10 mm) were created in the femoral condyles of 10 miniature pigs. The defects were left empty (E), filled with the grafted cylinder upsid...

Monoamine oxidases (MAOs) generate H(2)O(2) as a by-product of their catalytic cycle. Whether MAOs are mediators of endothelial dysfunction is unknown and was determined here in the angiotensin II and lipopolysaccharide-models of vascular dysfunction in mice. Quantitative real-time polymerase chain reaction revealed that mouse aortas contain enzymes involved in catecholamine generation and MAO-...