The early stages of thin film formation by thermal atom deposition are modeled by a system of kinetic rate equations which describe atomic clustering phenomena. Specifically, a set of discrete kinetic rate equations, used to model small atomic clusters, is coupled to a set of kinetic moment equations which model large atomic clusters with a continuum description. Cluster growth and dissociation...

t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

We propose a new method for creating an optimal coherence in a two-level system (TLS) based on adiabatic following. Optimal coherence is achieved by choosing the time-dependent phase of the pulse that provides vanishing field-TLS detuning dðtÞ at central time when the pulse amplitude reaches maximum. For example, dðtÞ 1⁄4 d0ð1 expððt t0Þ=s0ÞÞ for t 6 t0 and d 1⁄4 0 for t > t0. The pulse envelop...

FocalinTM XR (dexmethylphenidate hydrochloride) extended-release capsules is an extended-release formulation of dexmethylphenidate with a bi-modal release profile. FocalinXR uses the proprietary SODASTM (Spheroidal Oral Drug Absorption System) technology. Each bead-filled Focalin XR capsule contains half the dose as immediate-release beads and half as enteric-coated, delayed-release beads, thus...

Electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (ESI-MS/MS) data of a unique family of complexes of nitroso compounds coordinated to pentachloroiridate(III), [Cl5IrN(O)XR]2- (X=NH, S, CH and R=alkyl, aryl) are presented. These novel complexes are obtained by nucleophilic attack of primary amines, thiols. and alkenes to the coordinated nitrosyl. Despite their labi...

The activation of type I IFN signaling is a major component of host defense against viral infection, but it is not typically associated with immune responses to extracellular bacterial pathogens. Using mouse and human airway epithelial cells, we have demonstrated that Staphylococcus aureus activates type I IFN signaling, which contributes to its virulence as a respiratory pathogen. This respons...

We report results from a computational study of film cooling from cylindrical holes inclined at 35 degrees with respect to a flat surface using Large Eddy Simulations (LES). The hole length is L/d = 3.5, distance between the holes is P/d = 3, boundary layer above the flat surface is turbulent with Reθ = 938, density ratio = 0.95, velocity ratio = 0.5. All pertinent components of geometry, namel...

BACKGROUND Tissue engineering is used for the treatment of many diseases, and the ideal cell source for cartilage tissue engineering is chondrocytes. The main limitation of chondrocyte is the low number of cells in cartilage tissue engineering. This study investigated a suitable cell source with high proliferation rate to obtain a large number of chondrocytes. METHODS Adult cartilage t...

Extreme Requirements (XR) is a proposal that tries to improve the quality of Extreme Programming (XP). XP is a well known agile method for software production. XP key elements are: little documentation, simplicity, analysis as constant activity, evolutionary design, integration and daily test. XR defines a requirements strategy that can be coupled with XP. In this article, we present an XR busi...