نتایج جستجو برای: xpert mtbrif assay

تعداد نتایج: 222590  

Journal: :Asian Journal of Pharmaceutical and Clinical Research 2016

2018
Neeraj Raizada Sunil D Khaparde Virender Singh Salhotra Raghuram Rao Aakshi Kalra Soumya Swaminathan Ashwani Khanna Kamal Kishore Chopra M Hanif Varinder Singh K R Umadevi Sreenivas Achuthan Nair Sophie Huddart C H Surya Prakash Shalini Mall Pooja Singh B K Saha Claudia M Denkinger Catharina Boehme Sanjay Sarin

BACKGROUND Diagnosis of TB in children is challenging, and is largely based on positive history of contact with a TB case, clinical and radiological findings, often without microbiological confirmation. Diagnostic efforts are also undermined by challenges in specimen collection and the limited availability of high sensitivity, rapid diagnostic tests that can be applied with a quick turnaround t...

2012
Susan E. Dorman Violet N. Chihota James J. Lewis Maunank Shah David Clark Alison D. Grant Gavin J. Churchyard Katherine L. Fielding

BACKGROUND Xpert MTB/RIF ("Xpert") is a molecular test for detection of Mycobacterium tuberculosis (MTB) in sputum. Performance characteristics have been established for its use during passive tuberculosis (TB) case detection in symptomatic TB suspects, but Xpert performance has not been assessed in other settings. Objectives were to determine Xpert performance and costs in the context of a TB ...

2017
Maryline Bonnet Kim Chamroeun San Yati Pho Chandara Sok Jean-Philippe Dousset William Brant Northan Hurtado Khun Kim Eam Elisa Ardizzoni Seiha Heng Sylvain Godreuil Wing-Wai Yew Cathy Hewison

Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >12-months...

2017
J. L. Kandler M. N. Ezewudo S. P. Burns J. E. Posey

Study Design: Traditionally, Mycobacterium tuberculosis complex (MTB-complex) is identified by conventional methods. However, molecular methods are now being used more often. The previous algorithm of acid fast bacilli (AFB) smear positive patients who were new to the Bureau of Clinical Laboratories (BCL) was run on the GeneXpert automatically. The Xpert® MTB/RIF assay, performed on the GeneXpe...

Journal: :Clinical chemistry 2007
Emily S Winn-Deen Bret Helton Reuel Van Atta Wendy Wong Jeffrey Peralta James Wang Gregory J Tsongalis Dorothy Belloni David Chan James R Eshleman Christopher D Gocke Zsolt Jobbagy Lan Beppu Jerald P Radich

BACKGROUND Current practice guidelines for managing patients with chronic myelogenous leukemia (CML) call for monitoring BCR-ABL transcript concentrations with a quantitative reverse transcription-PCR (qRT-PCR) assay. Because the available laboratory-developed assays lack consensus on the appropriate design, reporting of results, and reference intervals, we developed and evaluated an integrated...

2017
Joshua Iruedo Don O’Mahony Sikhumbuzo Mabunda Graham Wright Busisiwe Cawe

BACKGROUND There are significant delays in initiation of multidrug-resistant tuberculosis (MDR -TB) treatment. The Xpert MTB/RIF test has been shown to reduce the time to diagnosis and treatment of MDR-TB predominantly in urban centres. This study describes the time to treatment of MDR-TB and the effect of Xpert MTB/RIF on time to treatment in a deprived rural area in South Africa. METHODS Th...

2011
Lesley E. Scott Kerrigan McCarthy Natasha Gous Matilda Nduna Annelies Van Rie Ian Sanne Willem F. Venter Adrian Duse Wendy Stevens

BACKGROUND The Xpert MTB/RIF (Cepheid) non-laboratory-based molecular assay has potential to improve the diagnosis of tuberculosis (TB), especially in HIV-infected populations, through increased sensitivity, reduced turnaround time (2 h), and immediate identification of rifampicin (RIF) resistance. In a prospective clinical validation study we compared the performance of Xpert MTB/RIF, MTBDRplu...

2014
Radha Rajasingham Kate Klammer Henry Nabeta Abdu Musubire Andrew Akampurira Darlisha Williams David Boxrud Melissa Rolfes Supatida Tengsupakul Alfred Andama Joshua Rhein David Meya David Boulware

There is limited understanding of the epidemiology of meningitis among human immunodeficiency virus (HIV)-infected populations in sub-Saharan Africa. We conducted a prospective cohort study of HIV-infected adults with suspected meningitis in Uganda, to comprehensively evaluate the etiologies of meningitis. Intensive cerebrospiral fluid (CSF) testing was performed to evaluate for bacterial, vira...

2017
Rosa Catarino Pierre Vassilakos Aline Bilancioni Stéphanie Bougel Meriem Boukrid Ulrike Meyer-Hamme Patrick Petignat

BACKGROUND Polymerase chain reaction-based Xpert human papillomavirus (HPV) assay is a rapid test that detects high-risk HPV (hrHPV) infection. This point-of-care test is usually performed by collecting a cervical specimen in a vial of PreservCyt® transport medium. We compared HPV test positivity and accuracy between self-collected sample with a dry swab (s-DRY) versus physician-collected cervi...

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