A large body of literature suggest that vascular reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases are important sources of reactive oxygen species. Many studies, however, relied on data obtained with the inhibitor apocynin (4 -hydroxy-3 methoxyacetophenone). Because the mode of action of apocynin, however, is elusive, we determined its mechanism of inhibition on vascular NAD...

Solid-based residues (SBRs) of Cordyceps militaris are often considered as waste after the cultivation fruiting body. To demonstrate value this by-product, different ratios two favorable green solvents (EtOH and water) were employed to optimize yields cordycepin (Cor) adenosine (Ado) investigate relevant activities plant growth inhibition (allelopathy), antioxidants, xanthine oxidase. The SBR e...

Ceruloplasmin (CP) was found to inhibit xanthine oxidase and ferritin-dependent peroxidation of phospholipid liposomes, as evidenced by decreased malondialdehyde formation. Ceruloplasmin was also shown to inhibit superoxide-mediated mobilization of iron from ferritin, in a concentration-dependent manner, as measured spectrophotometrically using the iron(II) chelator bathophenanthroline sulfonat...

Famciclovir, a 9-substituted guanine derivative, is a new antiviral agent which undergoes rapid hydrolysis and oxidation in man to yield the active antiherpes agent, penciclovir. Studies with human liver cytosol have indicated that the oxidation of the penultimate metabolite, 6-deoxypenciclovir, to penciclovir is catalyzed by the molybdenum hydroxylase, aldehyde oxidase. In the present study th...

BACKGROUND/AIMS Homovanillamine is a biogenic amine that it is catalyzed to homovanillyl aldehyde by monoamine oxidase A and B, but the oxidation of its aldehyde to the acid derivative is usually ascribed to aldehyde dehydrogenase and a potential contribution of aldehyde oxidase and xanthine oxidase is usually ignored. METHODS The present investigation examines the metabolism of homovanillami...

The products of the activity of xanthine oxidase (EC 1.2.3.2) include such reactive substances as H,O,, singlet oxygen and the superoxide and hydroxyl free radicals (KeUogg & Fridovich, 1975), which are currently receiving considerable attention not only because they lead to the formation of lipid hydroperoxides, but also because the latter may promote the formation of prostaglandins (Hemler et...

The influence of dietary protein on the activity of rat liver xanthine oxidase has been studied by several workers (l-5) and would point to a relationship between the availability of amino acids and the activity of liver xanthine oxidase (2). It has been demonstrated that the loss of liver xanthine oxidase activity in the rat greatly exceeds the loss of liver protein during acute inanition (l),...

A large body of literature suggest that vascular reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases are important sources of reactive oxygen species. Many studies, however, relied on data obtained with the inhibitor apocynin (4'-hydroxy-3'methoxyacetophenone). Because the mode of action of apocynin, however, is elusive, we determined its mechanism of inhibition on vascular NAD...

Picea koraiensis Nakai (PK) is an evergreen tree. It plays important role in landscaping and road greening. Insect galls of PK are formed by parasitism the adelgid Adelges laricis. Except for phenolics, other chemical constituents biological activity insect gall from still unknown. Thus, here, we performed phytochemical analyses extracts, aiming to turn waste into treasure serve human health. e...

Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an inhibitor of the prooxidant enzyme xanthine oxidase. Here, we established in a rodent model the capacity of allopurinol to be taken up by the mother, cross the placenta, rise to therapeutic levels...