Despite the prevalence of different kinds of wounds among people around the world, challenges ahead for managing wound healing continues. One of the most important issues for wound healing is infection that can delay healing process. Also, drug-resistant infections are growing as a worrying challenge in medicine. A lot of studies done over different methods to improve wound healing process, whi...

abstract background: pressure ulcer is one of the main concerns of nurses in medical centers around the world, which, if untreated, causes irreparable problems for patients. in recent years, nitric oxide (no) has been proposed as an effective method for wound healing. this study was conducted to determine the effect of nitric oxide on pressure ulcer healing. materials and methods: in this clini...

OBJECTIVES to establish if access to distal arterial reconstructive surgery is equally distributed within the health boards of Scotland and to establish if any variations in practice are reflected in lower limb amputation. METHODS a retrospective, descriptive study using hospital discharge data (Scottish Morbidity Record-1) from 1989 to 1999. RESULTS the rate of distal arterial reconstructi...

objective: to assess the effects of platelet rich plasma (prp) with chitosan biodegradable film on full thickness wound healing in rat. methods: this was an experimental study being performed in 2015 during a 4-month period. twenty-four male white wistar rats were divided into four groups of 12 rats each, randomly: control group (sham) with creation of wounds and no treatment, prp group with cr...

BACKGROUND The treatment options available for extremity sarcomas are amputation or limb-sparing surgery with radiation, which may incur significant morbidity and body disfigurement. Hyperthermic isolated limb perfusion (HILP) may be an attractive option in extremity sarcomas for unresectable lesions to preserve limb function and maintain quality of life. METHODS We report the outcomes of 5 p...

background: this study was designed to investigate the efficacy of pentoxifylline (ptx) in the treatment of irradiated wounds. materials and methods: ten female pigs of the large white strain were used in these investigations. six skin fields, 4 * 4 cm and separated from each other by 4 cm, were marked out on each flank and those on left flank were irradiated with 18gy single dose of 250 kv x-r...

Chronic critical limb ischemia (CLI) represents the extreme spectrum of peripheral arterial disease (PAD), accounting for about 1% to 3% of all PAD patients. CLI manifests as ischemic rest pain, gangrene and/or ulceration. CLI is considered chronic when symptoms persist for more than 2 weeks. It occurs when skin perfusion pressure at the affected site is reduced to a degree such that tissues’ r...

We report the sequential use of a pedicled fillet foot flap in a clinical case of complex bilateral lower extremity trauma to achieve stable wound closure, maximizing length preservation and gait rehabilitation. In addition, we perform a literature review of the use of fillet foot flaps in lower extremity trauma.

Background Abdominal aortic aneurysms (AAA) are a major cause of morbidity and mortality in the US. The most common location of AAA is the infrarenal abdominal aorta where oscillatory flow is present over the cardiac cycle, figure 1. Oscillatory flow is known to initiate an inflammatory response in endothelial cells. Patients with lower extremity traumatic amputations have a 5-fold increase in ...

Purpose Acute compartment syndrome often requires additional surgery to achieve wound closure. Little information exists regarding the expected number of surgeries, techniques and complications after closure in paediatric patients. Methods A retrospective chart review identified patients treated for acute compartment syndrome at four hospitals over a ten-year period. The cause of injury, type...