We present results relevant to the equilibrium organization of DNA strands of arbitrary length interacting with a spherical organizing center, suggestive of DNA-histone complexation in nucleosomes. We obtain a rich phase diagram in which a wrapping state is transformed into a complex multi-leafed structure as the adhesion energy is reduced. The statistical mechanics of the “melting” of a rosett...

Exercise may have both a preventive and a therapeutic impact on mental health problems. The Exercise without Worries intervention aims to reduce stress and depressive symptoms in low-SES women by means of a group-based program combining physical exercise and psycho-education. Between September 2005 and May 2008, 161 Dutch low-SES women with elevated stress or depressive symptom levels were rand...

Low-intensity interventions for people suffering from depressive symptoms are highly desirable. The aim of the present study was to investigate the outcomes of a web-based acceptance and commitment therapy (ACT)-based intervention without face-to-face contact for people suffering from depressive symptoms. Participants (N = 39) with depressive symptoms were randomly assigned to an Internet-deliv...

Previously, we had proposed a gravitational wave detector that incorporates the white-light-cavity (WLC) effect using a compound cavity for signal recycling (CC-SR). Here, we first use an idealized model for the negative dispersion medium (NDM) and use the so-called Caves model for a phase-insensitive linear amplifier to account for the quantum noise (QN) contributed by the NDM, in order to det...

OBJECTIVE The study examined the relative efficacy of online (NET) versus clinic (CLIN) delivery of cognitive behavior therapy (CBT) in the treatment of anxiety disorders in adolescents. METHOD Participants included 115 clinically anxious adolescents aged 12 to 18 years and their parent(s). Adolescents were randomly assigned to NET, CLIN, or wait list control (WLC) conditions. The treatment g...

In the present paper, we have studied a discrete version of the WLC model, which incorporates the spatial constraints imposed by the magnetic tweezer, used in current micro-manipulation experiments. These obstruction effects are relevant for “short” molecules, involving about two thousand base pairs or less. Two elements of the device have to be considered: first, the fixed plastic slab on whic...

OBJECTIVE Computerized cognitive-bias modification (CBM) protocols are rapidly evolving in experimental medicine yet might best be combined with Internet-based cognitive behavioral therapy (iCBT). No research to date has evaluated the combined approach in depression. The current randomized controlled trial aimed to evaluate both the independent effects of a CBM protocol targeting imagery and in...