نتایج جستجو برای: wilms tumor

تعداد نتایج: 428548  

2007
Ajit Mahale Vinaya Poornima Manish Shrestha Manish K Shrestha

The WAGR syndrome is a multiple congenital anomaly–mental retardation syndrome caused by interstitial deletion of the distal portion of chromosome 11p13. It is a contiguous gene deletion syndrome, and WAGR is an acronym for the primary features: W for Wilms tumor, A for aniridia, G for genital anomalies, and R for mental retardation. Wilms tumor and male genital anomalies are caused by deletion...

Journal: :Genetics and molecular research : GMR 2010
E T Valera M S Brassesco C A Scrideli L G Tone

Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones of tumor cells were observed, with DNA content varying from diploid t...

Journal: :Cancer research 2006
Rachael Natrajan Jorge S Reis-Filho Suzanne E Little Boo Messahel Marie-Anne Brundler Jeffrey S Dome Paul E Grundy Gordan M Vujanic Kathy Pritchard-Jones Chris Jones

Most Wilms' tumors are of low stage, favorable histology, and have a high likelihood of cure with current multimodal therapy. Despite this, there remains a group of patients whose tumors recur for whom intensive salvage regimens result in survival of only 50%. Fitting a Cox proportional hazards model to microarray-based comparative genomic hybridization (aCGH) data on 68 Wilms' tumor samples, w...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Rachael Natrajan Suzanne E Little Jorge S Reis-Filho Lara Hing Boo Messahel Paul E Grundy Jeffrey S Dome Toni Schneider Gordan M Vujanic Kathy Pritchard-Jones Chris Jones

PURPOSE The most well established molecular markers of poor outcome in Wilms' tumor are loss of heterozygosity at chromosomes 1p and/or 16q, although to date no specific genes at these loci have been identified. We have previously shown a link between genomic gain of chromosome 1q and tumor relapse and sought to further elucidate the role of genes on 1q in treatment failure. EXPERIMENTAL DESI...

Journal: :Journal of the American Society of Nephrology : JASN 2007
Zoia B Levashova Nirmala Sharma Olga A Timofeeva Jeffrey S Dome Alan O Perantoni

Although originally identified as mediators of inflammation, it is now apparent that chemokines play a fundamental role in tissue development. In this study, ELR(+)-CXC chemokine family members CXCL2 and CXCL7, along with their preferred receptor CXCR2, were expressed at the earliest stages of metanephric development in the rat, and signaling through this receptor was required for the survival ...

Journal: :Molecular cancer therapeutics 2013
Daniela Perotti Peter Hohenstein Italia Bongarzone Mariana Maschietto Mark Weeks Paolo Radice Kathy Pritchard-Jones

The European Network for Cancer Research in Children and Adolescents consortium organized a workshop in Rome, in June 2012, on "Biology-Driven Drug Development Renal Tumors Workshop" to discuss the current knowledge in pediatric renal cancers and to recommend directions for further research. Wilms tumor is the most common renal tumor of childhood and represents a success of pediatric oncology, ...

2013
Katsuhiko Yoshizawa Yuichi Kinoshita Yuko Emoto Ayako Kimura Norihisa Uehara Takashi Yuri Nobuaki Shikata Airo Tsubura

N-Methyl-N-nitrosourea (MNU)-induced renal tumors in rats and Wilms tumors in humans were compared. Renal mesenchymal tumors (RMTs) and nephroblastomas (blastemal and epithelial components) in female Lewis rats treated with a single intraperitoneal injection of 50 mg/kg MNU at birth and Wilms tumors (blastemal, epithelial and mesenchymal components) in humans were analyzed for the expression of...

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