Purpose A clinical trial was conducted employing androgen deprivation therapy (ADT) +/vaccine in patients (pts) with rising prostate specific antigen (PSA) after definitive therapy but no disease visible on bone or computed tomography (CT) scan. The primary endpoint was to determine if a whole tumor cell vaccine could prolong PSA recovery, but a key secondary endpoint was to evaluate the impact...

Immune adjuvants aimed at initiating or re-activating host immunity against poorly immunogenic cancers represent a potential tool for immunotherapy. By employing the natural killer T (NKT) cell agonist α-galactosylceramide in a whole tumor cell therapeutic vaccine approach, we have achieved potent suppression of established hematological cancers upon the elicitation of innate and adaptive antit...

INTRODUCTION Salmonella typhiVi capsular polysaccharide (ViCPS) is a licensed vaccine against typhoid fever in many countries; in Egypt, the killed whole-cell vaccine is still used. In this study, mice were used as an animal model to evaluate the immune response to ViCPS and other S. typhi antigens such as heat-killed whole cells and outer membrane protein (OMP). METHODOLOGY The three antigen...

background: potency test for control of rubella vaccine is a significant factor to qualify production line and vaccination pro­gram. for this reason, who recommends to use the microtitration method by both vaccine companies and control laborato­ries. then the study was done to improve this test. methods: three rubella virus samples, including an in-house standard, a lot of vaccine and an in- pr...

This report describes the preparation of a safe and immunogenic single vaccine against capripox disease in sheep and goats using two different types of cells (primary lamb kidney and vero, a bovine turbinate cell line). This used the 0240 pox strain isolated from sheep during an outbreak. The prepared vaccine was administered subcutaneously and induced complete protection against an experimenta...

Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated.   Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...

background: cell mediated immunity, especially cytotoxic t cell responses against hiv-1 infection, plays a critical role in controlling viral replication and disease progres-sion. dna vaccine is a novel technology which is known to stimulate strong cellular immune responses. many dna vaccines have been tested for hiv infection but there is still no effective vaccine against this infection. cons...

Cholera in pregnant women has been linked to higher rates of miscarriages and stillbirths. When used effectively, oral cholera vaccines (OCVs) can prevent or control cholera outbreaks and manage endemic cholera. For this reason, the World Health Organization (WHO) listed pregnant women in its 2010 position paper on cholera vaccines as a group that is “especially vulnerable to severe disease and...

Rise of diphtheria cases in adults is a cause of concern worldwide. Pertussis is also now affecting adults. We assessed serum levels of tetanus, diphtheria and pertussis antibodies in 62 adults in Pune, India, who had missed their primary immunization. All adults were then given three doses of tetanus-diphtheria (Td) vaccine at 0, 1, and 6 months. All adults were immune to tetanus but 78% had l...

A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice with the B. pertussis GroEL-like protein provided little protection against an ...