bone involvement. Destruction is mediated through normal osteoclasts, which respond to local osteoclast-activating microenvironment [7]. Technetium-99m 2methoxyisobutylisonitrile (TC-99m MIBI) is a lipophilic agent that accumulates within living malignant cells due to the higher transmembrane electrical potential as a consequence of the higher metabolic rate than in the surrounding normal cells...

Received 1/4/2005; revised 1/8/2005; accepted 1/18/2005. For correspondence or reprints contact: Bing-Fu Shih, M.D., Department of Nuclear Medicine, Mackay Memorial Hospital, 92 Section 2, Chung-Shan North Road, Taipei 104, Taiwan. Tel:(886)2-25433535 ext. 2241, Fax: (886)2-25433535 ext. 2925, E-mail:[email protected] Bone scintigraphy is a common and sensitive modality for detecting either...

a 54 years old female with history of total thyroidectomy for papillary carcinoma, treated with loomci of iodine-131 and negative whole body scans was referred for follow up study. tl-201 scan revealed an area of radiotracer uptake in the neck region, suggestive of a parathyroid adenoma versus recurrence of thyroid carcinoma. the patient was operated, the parathyroid adenoma was removed. in thi...

OBJECTIVES This study aims primarily to determine whether whole body MRI (WB-MRI) and Sestamibi Technetium-99m-bone marrow (MIBI) scans in the same patients produce the same estimate of disease load and location, and secondly, to study possible association between the bone disease detected by these scans and the effect on disease outcome and survival. Bone disease occurs in about 90% of multipl...

Urine bladder diverticula are usually asymptomatic, therefore they are incidentally diagnosed during examinations for other purposes. A Chinese patient, with a history of pulmonary adenocarcinoma first underwent a technetium-99m methylene diphosphonate whole-body bone scan. In addition to multiple skeletal metastases, abnormal shape of the urine bladder was also noted, which overlapped the supe...

The patient with a history of bone pain and muscle weakness, was thought to have oncogenic osteomalacia as a result of biochemical investigations and directed to Nuclear Medicine Department for a whole-body bone scintigraphy and 111In-octreotide scintigraphy. There was no focal pathologic tracer uptake, but generalized marked increase in skeletal uptake on bone scintigraphy. Octreotide scintigr...

Methods A 4-year old Caucasian female was diagnosed with DSMO and prospectively followed from 2007-2014. She presented with a 20-month history of facial asymmetry and painful bony expansion of the left hemimandible. CT-scan revealed bone expansion suggestive of fibrous dysplasia, but two consecutive bone biopsies revealed inflammatory cells only. Infectious osteomyeltis was also suspected, but ...

Background: Positron Emission Tomography-Computed Tomography (PET-CT) is a useful hybrid imaging modality in the diagnosis of various malignancies. This modality imposes almost 20 mSv radiation dose to the patient. The purpose of the present study was to evaluate the uncertainties in calculated CT effective dose in TUBE CURRENT MODULATION-activated scans by Impact-Dose software.  Materials and ...

BACKGROUND There is no general consensus on the optimal criteria for the application of bone scintigraphy in screening of bone metastasis in patients with prostate cancer. Our study was conducted to assess the value of bone scan for pre-treatment staging of asymptomatic treatment-naïve patients with prostate cancer. METHODS A total of 203 consecutive asymptomatic and treatment-naïve patients ...

The purpose of this prospective study was to evaluate Whole Body-MRI as a screening tool for bone marrow imaging in patients with multiple myeloma and monoclonal gammopathy. 22 cancer patients at initial diagnosis underwent Whole Body-MRI and conventional radiography in order to detect bone and bone marrow abnormalities. MRI was performed using a turbo-STIR-sequence combined with a rolling tabl...