A sensitivity analysis in an observational study determines the magnitude of bias from nonrandom treatment assignment that would need to be present to alter the qualitative conclusions of a naïve analysis that presumes all biases were removed by matching or by other analytic adjustments. The power of a sensitivity analysis and the design sensitivity anticipate the outcome of a sensitivity analy...

A meta-analysis was performed on five studies conducted over the last decade to demonstrate a positive effect for the drug Uro-Vaxom compared with Placebo in double-blind studies in patients with urinary tract infection (601 women), with special reference to the prevention of recurrences over an observation period of 6 months, the treatment being given for the first 3 months. The five studies w...

ion/Flexibility (Wisconsin Card SortingTest; Heaton et al, 1993) The percentage of perseverative errors was used as the central parameter. Statistical analyses Frequency counts and descriptive statistics were calculated for initial basic symptoms, observed and self-perceived psychopathology. Differences in initial psychopathology between those patients at risk who experienced a transition to ps...

Obesity is frequently associated with insulin resistance. Recently an important role of the cytokine tumor necrosis factor-alpha in mediating insulin resistance of obesity through its overexpression in fat tissue has been reported. In order to examine the relation of insulin resistance to obesity and to serum neopterin, as a parameter of immune activation, we studied 1234 otherwise healthy outp...

In a prospective, randomised trial of 81 patients with fractures of the ankle of AO types A, B and C we compared two regimes of postoperative management after internal fixation. The patients were mobilised either non-weight-bearing with crutches or weight-bearing in a below-knee walking plaster. We found a temporary benefit in subjective evaluation only (65 v 50 points, Mann-Whitney test, cft, ...