clozapine is the first antipsycotic drug with a great efficacy. thirty to fifty percent of treatment-resistant schizophrenics markedly improved with clozapine. approximately, 25% of long-term patients, treated with clozapine, could be discharged. this improvement included negative as well as positive symptom areas. clozapine produced no extrapyramidal side effects. tardive dyskinesia, a major s...

The reticulum cell sarcoma (RCS) 1 of S JL / J mice has been shown to express alien histocompatibility membrane antigens (1, 2). This form of tumor antigen is, by definition, present on cancerous, but not normal, syngeneic tissues. However, it differs from other forms of tumor-associated antigens because it is a normal membrane component of one or more strains allogeneic to the host (3). In the...

A series of tests has been completed comparing the system performance of four long term replacements HP62 (44% R~125/ 54% R-143a/ 4% R-134a), AZ-50 (50% R-125/ 50% R-143a), Klea 60 (20% R-32/ 40% R-125/ 40% R-134a), and Klea 61 (1 0% R-32/ 70% R-125/ 20% R-134a) as potential alternatives for the CFC-containing low temperature refrigerant R-502. The tests were carried out under controlled condit...

Division of Cardiology, Department of Medicine (DGS, JACL, JMM, GG, RGW, GFT, KCW), 12 Johns Hopkins Medical Institutions, Baltimore, MD Duke Clinical Research Institute (DGS, GSW), Durham, NC, 14 Department of Clinical Physiology (DGS, HA), Lund University Hospital, Sweden Memorial Hospital Research Center (RHS), Long Beach, CA 16 Cedars-Sinai Heart Institute (EM), Los Angeles, CA. 18 Address ...

PROLIFERATION VIA CYCLIN-DEPENDENT KINASES Abdullah Yalcin, Brian F. Clem, Alan Simmons, Andrew Lane, Kristin Nelson, Amy L. Clem, Erin Brock, Deanna Siow, Binks Wattenberg, Sucheta Telang and Jason Chesney Division of Medical Oncology (Molecular Targets Group), James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202 Department of Biochemistry, School of Veterinar...

objective: the usage of pesticides has increased during the recent years. one the other hand, presence of harmful pesticides residue in rice and other food has caused a great concern among the consumers. therefore, it is important to develop some pragmatic procedures to increase the food safety along with the reduction in consumption of pesticide residues. methods: a gas chromatograph with elec...

Oligodendrocyte precursor cells (OPCs) are thought to maintain homeostasis and contribute to long-term repair in adult white matter; however, their roles in the acute phase after brain injury remain unclear. Mice that were subjected to prolonged cerebral hypoperfusion stress developed white matter demyelination over time. Prior to demyelination, we detected increased MMP9 expression, blood-brai...

Activity of the hypothalamic-pituitary-adrenal axis (measured via cortisol reactivity) may be a biological marker of risk for depression and anxiety, possibly even early in development. However, the structural neural correlates of early cortisol reactivity are not well known, although these would potentially inform broader models of mechanisms of risk, especially if the early environment furthe...