INTRODUCTION To evaluate the complications, efficacy of medical and surgical treatment, and outcome in patients with necrotizing scleritis and peripheral ulcerative keratitis associated with Wegener's granulomatosis. METHODS The authors reviewed a series of seven patients with Wegener's granulomatosis treated in the Corneal Department of Zhongshan Ophthalmic Center and the Department of Ophth...

Sarcoidosis is a granulomatous disease of unknown aetiology. We identified immunological targets for the treatment of pulmonary granulomatosis using a murine model generated with Propionibacterium acnes. Sensitisation and challenge using heat-killed P. acnes and dendritic cells (DCs) were performed to produce pulmonary granulomatosis in C57BL/6 mice. Immunological analyses using ELISA as well a...

Objectives. To illustrate the only reported case of Wegener’s granulomatosis limited to the head and neck, and to provide an update on current knowledge and treatment of Wegener’s granulomatosis. Case report. A 50-year-old man presented with bilateral chronic otitis and mastoiditis, eventually developing bilateral facial palsies. While he progressed with other head and neck symptoms, his diseas...

Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a rare immunological small vessel disease which usually affects respiratory tract and kidneys. However, salivary gland involvement in GPA primary manifestation. We report case of the presentation submandibular involvement. A 48-year-old female patient presented swelling skin defect that lasted for 1 month. Al...

BACKGROUND Granulomatosis with polyangiitis is a rare multisystemic autoimmune disorder predominantly affecting the upper and lower respiratory tracts and the kidneys, and rarely affecting other organ systems. Tuberculosis can mimic the presentation of granulomatosis with polyangiitis, and both can occur simultaneously in the same patient. Here we report what we believe to be the first case of ...

UNLABELLED INTRODUCTION Wegener's granulomatosis presenting as diffuse alveolar hemorrhage is uncommon. However, the recognition of multisystem disease involving joints, kidney, eye and lung is critical for diagnosing Wegener's vasculitis. This is not the first report of this kind in the literature. CASE PRESENTATION A 51-year-old Croatian woman presented to our Emergency Department with a...

Introduction. Pulmonary Langerhans cell granulomatosis is a rare disease with a variable course. In pulmonary Langerhans cell granulomatosis pulmonary hypertension is frequent and has an independent prognostic impact. A vasculopathy which ist not related to ventilatory disturbance and fibrosis has been identified. An arteriopathy and even a venulopathy have been described. Due to this possible ...

3. Gonzalez-Gay MA, Garcia-Porrua C, Guerrero J, Rodriguez-Ledo P, Llorca J. The epidemiology of the primary systemic vasculitides in northwest Spain: implications of the Chapel Hill Consensus Conference definitions. Arthritis Rheum. 2003;49:388–93. 4. McCluskey P, Powell RJ. The eye in systemic inflammatory diseases. Lancet. 2004;364:2125–33. 5. Tarabishy AB, Schulte M, Papaliodis GN, Hoffman ...

Takanobu Kan'", Shun$uke Takahagi'", Akiko Kamegashira', Hiroshi Ooiwa^ Takashi YaguchP and Michihiro Hide'* 'Department of Dermatology, Programs for Biomédical Researcii, Division of Molecular Medicai Science, Graduate School of Biomédical Sciences, -Department of Clinicai Immitnoiogy and Rlieumatology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, and ^Medical Mycology Re...