In this series of studies, we determined the potential role of intracellular estrogen receptors (ER), ER and ER , on macrophage function in response to bacterial stimuli. The sex hormone 17 -estradiol (E2) and ER have been shown to modulate inflammatory responses as well as T helper cell type 1 (TH1)/TH2 responses. The mechanisms E2 and its receptors use to alter these immune functions remain l...

It has been an open problem to derive a necessary and sufficient condition for a linear tensor product problem S = {Sd} in the average case setting to be weakly tractable but not polynomially tractable. As a result of the tensor product structure, the eigenvalues of the covariance operator of the induced measure in the one dimensional problem characterize the complexity of approximating Sd, d ≥...

Background: Whether AGR2 promotes adenocarcinoma growth as a secreted or ER localized protein is not known. Results: A unique C-terminal motif, KTEL, is required for AGR2 ER localization and function. Conclusions: Not all ER localization motifs are interchangeable. Significance: Specific ER localization signals may be required for protein function. AGR2's tumor promoting effects are mediated fr...

BACKGROUND To identify and estimate the prevalence of mediastinal cysts lined by the epithelium expressing steroid receptors. METHODS We retrieved 19 mediastinal cysts from our pathology files from 1996 to 2004, and examined estrogen receptor (ER) and progesterone receptor (PR) expressions in the cysts. RESULTS Three paravertebral cysts, all in women, one bronchogenic cyst in a woman, nine ...

In 1965, Njastad [2] introduced the notion of α-sets in topological space. In 1983, Mashhour et al. [1] introduced, with the help of α-sets, a weak form of continuity which they termed as α-continuity. Noiri [3] introduced the same concept, but under the name strong semicontinuity. Noiri [4] defined with the aid of α-sets a new weakened form of continuous mapping called weakly α-continuous mapp...

In this issue of the Journal, Gomez-Fernandez et al 1 report their experience with estrogen receptor (ER) immu-nohistochemical expression in 278 patients with recurrent and/or metastatic breast cancer. By using ER antibody 1D5, they found that 9 of 159 previously positive cases (5.7%) did not express ER in their metastatic or recurrent sites. In addition , of 119 initially ER– primary breast ca...

In response to endoplasmic reticulum (ER) stress, cells launch homeostatic and protective responses, but can also activate cell death cascades. A 54 kDa integral ER membrane protein called Herp was identified as a stress-responsive protein in non-neuronal cells. We report that Herp is present in neurons in the developing and adult brain, and that it is regulated in neurons by ER stress; subleth...

Myocardial blood flow is spatially heterogeneous, reflecting nonuniform oxygen supply. Also, myocardial oxidative metabolism is spatially heterogeneous. The effects of acute ischemia and reperfusion on the relationship between local myocardial blood flow (LMF) and oxidative metabolism are still unknown. LMF was measured in isolated, blood-perfused rabbit hearts using colored microspheres and ox...

The hippocampal system plays an important role in memory function. Neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. Many biological effects of estrogens in the brain via estrogenic receptors (ERs) are investigated. The current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...

In this technical report, we present a bunch of methods for the task 4 of Detection and Classification of Acoustic Scenes and Events 2017 (DCASE2017) challenge. This task evaluates systems for the large-scale detection of sound events using weakly labeled training data. The data are YouTube video excerpts focusing on transportation and warnings due to their industry applications. There are two ...