نتایج جستجو برای: weak base

تعداد نتایج: 393981  

Journal: :Methods and applications in fluorescence 2016
Young Min Lee Sun-Young Park Heesu Kim Taeg Gyum Kim Oh-Hoon Kwon

The excited-state proton transfer (ESPT) of the strong photoacid, N-methyl-7-hydroxyquinolinium, was studied in the presence of different weak bases such as methanol, ethanol, and dimethyl sulfoxide in an aprotic solvent of acetonitrile. Here, we present chemical kinetics analysis of the ESPT mechanism to explain biphasic fluorescence decay of the parent photoacid and the sign reversal of the r...

Journal: :Molecular cancer therapeutics 2006
Leo E Gerweck Shashirekha Vijayappa Sergey Kozin

The extracellular pH of tumor tissue is significantly lower than the extracellular pH of normal tissue, whereas the intracellular pH of both tissues is similar. In principle, extracellular acidity may be expected to enhance the intracellular uptake and cytotoxicity of weak acid chemotherapeutics that are membrane permeable in their uncharged state and inhibit the efficacy of weak bases. However...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2010
Igor V Zhigaltsev Geoff Winters Masuna Srinivasulu Jason Crawford Matthew Wong Lawrence Amankwa Dawn Waterhouse Dana Masin Murray Webb Natashia Harasym Lindsay Heller Marcel B Bally Marco A Ciufolini Pieter R Cullis Norbert Maurer

Hydrophobic uncharged drugs such as docetaxel are difficult to encapsulate and retain in liposomal nanoparticles (LNP). In this work we show that a weak base derivative of docetaxel can be actively loaded into LNP using pH gradient loading techniques to achieve stable drug encapsulation and controlled release properties. Docetaxel was derivatized at the hydroxyl group in the C-2' position to fo...

2004
Susan E. Burke Christopher J. Barrett

Multilayer thin films prepared from weak polyelectrolytes can exhibit a rich suite of anomalous physicochemical properties. One of the major factors that influence the properties of such films is the acid/base chemistry of the weak functional groups of the polyelectrolytes. In fact, the apparent dissociation constants of weak polyelectrolytes can shift by as much as 1–4 pH units upon incorporat...

2007
Alan Shuchat Randy Shull Ann N. Trenk

In this paper we describe the range of values that can be taken by the fractional weak discrepancy of a poset subject to forbidden r+ s configurations, where r+s = 4. Generalizing previous work on weak discrepancy in [5, 12, 13], the notion of fractional weak discrepancy wdF (P ) of a poset P = (V,≺) was introduced in [7] as the minimum nonnegative k for which there exists a function f : V → R ...

Journal: :Critical Care 2005
Thomas J Morgan

Stewart's quantitative physical chemical approach enables us to understand the acid-base properties of intravenous fluids. In Stewart's analysis, the three independent acid-base variables are partial CO2 tension, the total concentration of nonvolatile weak acid (ATOT), and the strong ion difference (SID). Raising and lowering ATOT while holding SID constant cause metabolic acidosis and alkalosi...

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