نتایج جستجو برای: weak base
تعداد نتایج: 393981 فیلتر نتایج به سال:
The excited-state proton transfer (ESPT) of the strong photoacid, N-methyl-7-hydroxyquinolinium, was studied in the presence of different weak bases such as methanol, ethanol, and dimethyl sulfoxide in an aprotic solvent of acetonitrile. Here, we present chemical kinetics analysis of the ESPT mechanism to explain biphasic fluorescence decay of the parent photoacid and the sign reversal of the r...
The extracellular pH of tumor tissue is significantly lower than the extracellular pH of normal tissue, whereas the intracellular pH of both tissues is similar. In principle, extracellular acidity may be expected to enhance the intracellular uptake and cytotoxicity of weak acid chemotherapeutics that are membrane permeable in their uncharged state and inhibit the efficacy of weak bases. However...
Hydrophobic uncharged drugs such as docetaxel are difficult to encapsulate and retain in liposomal nanoparticles (LNP). In this work we show that a weak base derivative of docetaxel can be actively loaded into LNP using pH gradient loading techniques to achieve stable drug encapsulation and controlled release properties. Docetaxel was derivatized at the hydroxyl group in the C-2' position to fo...
Multilayer thin films prepared from weak polyelectrolytes can exhibit a rich suite of anomalous physicochemical properties. One of the major factors that influence the properties of such films is the acid/base chemistry of the weak functional groups of the polyelectrolytes. In fact, the apparent dissociation constants of weak polyelectrolytes can shift by as much as 1–4 pH units upon incorporat...
In this paper we describe the range of values that can be taken by the fractional weak discrepancy of a poset subject to forbidden r+ s configurations, where r+s = 4. Generalizing previous work on weak discrepancy in [5, 12, 13], the notion of fractional weak discrepancy wdF (P ) of a poset P = (V,≺) was introduced in [7] as the minimum nonnegative k for which there exists a function f : V → R ...
Stewart's quantitative physical chemical approach enables us to understand the acid-base properties of intravenous fluids. In Stewart's analysis, the three independent acid-base variables are partial CO2 tension, the total concentration of nonvolatile weak acid (ATOT), and the strong ion difference (SID). Raising and lowering ATOT while holding SID constant cause metabolic acidosis and alkalosi...
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