The behavior of gel layer thickness in swellable hydroxypropyl methyl cellulose matrices loaded with increasing amounts of soluble and colored drug and exhibiting swelling, diffusion and erosion fronts, was studied using a colorimetric technique. The effect of the drug loading on the front position in the gel layer, in particular, on the presence of a diffusion front and its movement, was inves...

The endothelial surface of the isolated rabbit cornea was perfused with modified KEI medium, according to the method reported previously. This in vitro cornea maintained its thickness within the normal range even after the epithelium ivas removed. The endothelial permeability of these in vitro corneas to tritiated water, >C-labeled urea, sucrose, and inulin teas determined. The reflection coeff...

Mechanical instabilities such as buckling, wrinkling, creasing, and folding are commonplace in both natural and synthetic systems over a wide range of length scales. In this study, we focus on the spontaneous folding behavior of the highly swellable confined nanoscale (thickness below 100 nm) gel films resulting in the formation of a network of regularly folded structures spontaneously emerging...

We probe, using the surface forces apparatus, the thermal response of poly(N-isopropylacrylamide) (PNIPAM) brushes of various grafting densities, grown from plasma-activated mica by means of surface-initiated polymerization. We thus show that dense thermoresponsive brushes collapse gradually as temperature is increased and that grafting density greatly affects their ability to swell: the swelli...

We studied the pH-responsive behavior of layer-by-layer (LbL) microcapsules fabricated from silk fibroin chemically modified with different poly amino acid side chains: cationic (silk-poly L-lysine, SF-PL) or anionic (silk-poly-L-glutamic acid, SF-PG). We observed that stable ultrathin shell microcapsules can be assembled with a dramatic increase in swelling, thickness, and microroughness at ex...

Phase behavior of didodecyl and dioctadecydimethylammonium bromide (DDAB and DODAB) in water was studied using X-ray techniques, differential scanning calorimetry and deuterium nuclear magnetic resonance measurements. Both surfactants self-assemble into lamellar liquid crystalline, either Lα (fluid) and Lβ (gel), phases. The gel-to-fluid phase transition temperature (Tm) in DDAB lamellae was fo...

Recent progress in modelling the solvent vapor annealing of thin film block copolymers is examined in the context of a self-consistent field theory framework. Key control variables in determining the final microdomain morphologies include swelling ratio or swollen film solvent volume fraction, swollen film thickness, substrate and vapor atmosphere surface energies, effective volume fraction, an...

BACKGROUND Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare thi...

Abstract Swelling of clay–sulfate rocks is a serious and devastating geo-hazard, often causing damage to geotechnical structures. Therefore, understanding underlying swelling processes crucial for the safe design, construction, maintenance infrastructure. Planning appropriate countermeasures problem requires thorough involved. We developed coupled hydro-mechanical (HM) model reproduce observed ...