A best evidence topic in cardiac surgery was written according to the structured protocol. The question addressed was about the best time to restart anticoagulation in patients with intracranial bleed with a prosthetic valve in situ. This difficult clinical decision has to balance the risk of thromboembolism during the period that the anticoagulation was reversed and later withheld vs the risk ...

OBJECTIVE To compare key features of the new oral anticoagulants (NOACs)-dabigatran, rivaroxaban, and apixaban-and to address questions that arise when comparing the NOACs. SOURCES OF INFORMATION PubMed was searched for recent (January 2008 to week 32 of 2013) clinical studies relating to NOAC use for stroke prevention in atrial fibrillation (AF) and for the treatment of acute venous thromboe...

Penyakit kardiovaskular didefinisikan sebagai penyakit akibat adanya gangguan fungsi jantung dan vaskuler. Salah satu terapi yang digunakan untuk adalah warfarin. Penggunaan warfarin pada diukur dengan parameter waktu prothrombin melalui nilai INR (International Normalized Ratio) target 2-3. Penelitian ini bertujuan mengetahui kesesuaian pasien di Poli Spesialis Jantung RS Roemani Muhammadiyah ...

OBJECTIVES Dabigatran, rivaroxaban, apixaban, and edoxaban are nonvitamin K antagonist oral anticoagulants (NOACs) approved for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF). Phase-3 clinical trials demonstrated NOACs were as effective as warfarin in the prevention of stroke or systemic embolism and associated with decreased incidences of intracranial bleeding. Addit...

INTRODUCTION Limited data exists for types of venous closure and its associated complications in patients after atrial fibrillation (AF) catheter ablation. We evaluated the subcutaneous figure-of-eight closure (FO8) for achieving venous hemostasis after AF catheter ablation compared to manual pressure. METHODS 284 consecutive patients that underwent AF catheter ablation by two operators were ...

Atrial fibrillation (AF) is the commonest cardiac rhythm disorder worldwide, affecting 1% of the general population. It is estimated that up to 16 million people in the US will suffer from the arrhythmia by 2050. AF is an independent stroke risk factor and associated with more severe strokes. For six decades, warfarin has been the only truly effective therapy to protect against stroke for patie...

BACKGROUND Extra-pericardial tamponade is a rare life threatening condition that has not previously been reported in association with Wolf Mini-Maze procedures. In this case, atypical presentation of cardiac tamponade caused by postoperative anticoagulation resulted in a second hospitalization, a second surgery, and delayed recovery time. The goal of this case report is to increase awareness ab...

Aim: Warfarin has a narrow therapeutic index. We aimed to evaluate the effect of frailty on compliance warfarin pharmacotherapy and attainment international normalised ratio (INR) goals in patients aged over 65 years receiving warfarin.
 
 Method: recruited 473 elderly subjects over. Indications for administration INR values were recorded. All assessed according Clinical Frailty Scale...