Warfarin resistance in the Norway rat (Rattus norvegicus) has been studied over the past 30 years. To determine the status of this resistance phenomenon wild Norway rats were collected from Colorado and Chicago, Illinois. As reported previously, warfarin resistance in the Chicago area exceeds 50%, while rats from Colorado remain very susceptible to warfarin. The theory that true genetic resista...

Warfarin skin necrosis (WSN) is an infrequent complication of warfarin treatment and is characterized by painful ulcerative skin lesions that appear a few days after the start of warfarin treatment. Calciphylaxis also appears as painful skin lesions caused by tissue injury resulting from localized ischemia caused by calcification of small- to medium-sized vessels in patients with end-stage rena...

Introduction: Using artificial intelligence tools in pharmacogenomics is one of the latest bioinformatics research fields. One most important drugs that determining its initial therapeutic dose difficult anticoagulant warfarin. Warfarin an oral that, due to narrow window and complex interrelationships individual factors, selection optimal challenging . Method: Inaccuracy warfarin will simply le...

Main results Analysis was by intention to treat. Both warfarin groups had lower rates for the main composite measure, nonfatal reinfarction, and thromboembolic stroke than the aspirin alone group (table); the 2 warfarin groups did not differ for these outcomes. The 3 groups did not differ for overall mortality. Both warfarin groups had higher rates for nonfatal major bleeding episodes than the ...

A 72-year-old man who had been taking rifampin daily for several months was concurrently administered warfarin daily for ten weeks. During this period, the prothrombin time (PT) rose remarkably little as the dosage of warfarin was increased. With difficulty, satisfactory anticoagulation was achieved by giving warfarin 20 mg daily. On discontinuation of rifampin therapy, the PT increased signifi...

Uric acid concentrations reportedly are increased in patients being treated with warfarin. We measured uric acid in 40 patients before and during warfarin administration. The mean pre- and post-warfarin uric acid concentrations for our patients were 0.39 mmol/L and 0.40 mmol/L, respectively, not a significant difference. Further observations of hyperuricemic patients started on warfarin are nee...

Warfarin is a critical medication that is broadly used for the treatment and prevention ofthromboembolic disorders. Due to warfarin’s narrow therapeutic index, it is crucial that patientsfollow an appropriate dosage regimen. Patient knowledge is one of the most important factorsto safe and effective use of warfarin. Due to the obvious risks of anticoagulants administration,<br...

Warfarin is a frequently prescribed anticoagulant in rehabilitation patients. Adverse drug reactions of warfarin were reported as bleeding and cutaneous microvascular thrombosis. Major bleeding, such as intracranial hemorrhage and psoas hematoma, in patients receiving anticoagulation therapy is a rare condition, but sometimes very serious complication that can even be fatal. Patient-specific fa...

AIM To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients. MATERIALS & METHODS We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threat...

Chinese patients are reportedly more sensitive than Caucasians to the anticoagulant effect of warfarin. We examined warfarin dose requirements and their determinants in 151 Chinese out-patients on stable maintenance dose of warfarin with international normalized ratio of 2 to 2.5. Mean daily warfarin requirement was 3.3 +/- 1.4 mg, much lower than reported doses in Caucasian patients. The most ...