Oritavancin is a lipoglycopeptide antibiotic under investigation for the treatment of serious infections caused by Gram-positive bacteria. Oritavancin has demonstrated rapid dose-dependent bactericidal activity towards vancomycin-susceptible and -resistant enterococci, meticillin-susceptible and -resistant Staphylococcus aureus, vancomycin-intermediate S. aureus (VISA), heteroresistant VISA (hV...

In this paper, we consider the maximizing of probability $${\mathbb {P}}\left\{ \, \zeta \mid \in {\mathbf {K}}({\mathbf {x}}) \right\} $$ over a closed and convex set $${\mathcal {X}}$$ , special case chance-constrained optimization problem. Suppose $${\mathbf \triangleq \left\{ {\mathcal {K}}\, c({\mathbf {x}},\zeta ) \ge 0 $$\zeta is uniformly distributed on compact {K}}$$ $$c({\mathbf )$$ d...

Staphylococcus aureus causes a variety of diseases in humans and other animals. Antibiotics used to treat the infections are becoming less effective due to drug resistance. Thus, new drugs must be found, possibly targeting proline transporters. Staphylococcus aureus must import proline and two separate proline transporters have been recognized. The putP gene encodes the high affinity proline tr...

Objective(s) Staphylococcus aureus is a foremost source of numerous nosocomial and community acquired infections. Antibiotic therapy for vancomycin resistant S. aureus (VRSA) can not promise the eradication of infections. Since adhesion is the major route of infections, adhesin based vaccine could suppress S. aureus infections. Fibronectin binding protein A (FnBPA) and clumping factor A (ClfA)...

results out of 238 samples, 5.88% were resistant to quinupristin-dalfopristin; 5.46% to linezolid; 60.92% to co-trimoxazole; 31.93% to doxycycline; 18.90% to tigecycline; 5.04% to vancomycin; 9.24% to mupirocin; 43% to oxacillin and 46.21% of our isolates were resistant to cefoxitin. conclusions coming across isolates with reduced susceptibility to quinupristin-dalfopristin and resistant to lin...