Background: Esketamine and ketamine have been shown to produce rapid antidepressant action in patients with treatmentresistant depression (TRD). The aim of the current study was to assess the efficacy, safety and dose response of intranasal esketamine in patients with TRD. Methods: This was a 2-Panel, doubly-randomized, double-blind, placebo-controlled, multicenter study. Panel A was conducted ...

Abstract The gravitational decoupling is applied to studying minimal geometric deformed (MGD) compact superfluid stars, in covariant logarithmic scalar gravity on fluid branes. brane finite tension shown provide more realistic values for the asymptotic value of mass function MGD besides constraining range self-interacting field, minimally coupled gravity. Several other physical features regulat...

Cognitive deficits constitute an integral part of clinical picture of depression, but often not enough attention has been paid to these deficits, mainly because of the presumption that they are secondary to typical depressive symptoms. It is considered that cognitive impairment is one of the main causes of depressive patients' poor functioning. Cognitive deficits are observed already in the fir...

Vortioxetine is a novel anti-major depression disorder drug with high safety profile compared other similar drugs. However, little research has been done on drug-drug interactions (DDI) about vortioxetine. In this paper, the inhibitory effect of vortioxetine cytochrome P450 (CYP450) and type mechanism were investigated in human rat liver microsomes. We set up an vitro incubation system 200 μL t...

In this work, an efficient slotted waveguide antenna (SWA) system is designed for S-band high power microwave (HPM) applications. The SWA comprises of 10-slot elements placed on the broad wall with a modified Gaussian distribution (MGD), integrated two inside-grooves and dielectric radome high-density polyethylene (HDPE) material. are introduced to suppress surface current waveguide, which resu...

PURPOSE To assess the clinical efficacy of a newly developed disposable eyelid-warming device (Eye Warmer) for the treatment of meibomian gland dysfunction (MGD). METHODS The Eye Warmer was applied for 5 minutes to 44 eyes of 22 patients who exhibited decreased tear break-up time (BUT) and dry-eye symptoms. Its efficacy was assessed on the basis of BUT and dry-eye symptoms in the short-term s...

The estimation of the mean glandular dose to the breast (MGD) for x-ray based imaging modalities forms an essential part of quality control and is needed for risk estimation and for system design and optimisation. This review considers the development of methods for estimating the MGD for mammography, digital breast tomosynthesis (DBT) and dedicated breast CT (DBCT). Almost all of the methodolo...

OBJECTIVE Gut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural changes. Interestingly, a magnesium restricted diet has been shown to induce anxiety and depressive-like behaviour in humans and rodents, and it could be suggested that magn...

OBJECTIVE To assess the value of preoperative sestamibi scanning and intraoperative parathyroid hormone (IOPTH) measurement in the treatment of patients with primary hyperparathyroidism due to multiple gland disease (MGD). DESIGN Retrospective medical record review. SETTING Tertiary care academic medical center. PATIENTS The study population comprised 383 consecutive patients who underwen...