Aim of this study was verifying whether mucin producing colon cancers (CRCs) could develop through a molecular pathway involving microsatellite instability (MSI) and MUC gene alterations. Out of 49 CRCs expressing variable amounts of mucin, 22 (44.9%) were MSI-H and 5 (10.2%) were MSI-L. MUC genes were analyzed by Southern blotting and extra bands were evident in the Variable Number Tandem Repe...

QUB11a is used as a locus for variable number of tandem repeats (VNTR) analysis of Mycobacterium tuberculosis Beijing lineage. However, amplification of QUB11a occasionally produces large fragments (>1,400 bp) that are not easily measured by capillary electrophoresis because of a lack of the typical stutter peak patterns that are used for counting repeat numbers. IS6110 insertion may complicate...

Amaç: Romatizmal kalp kapak hastalığının (RKKH)’da dahil olduğu çeşitli otoimmün ve kronik enflamatuvar hastalıklarda, IL-1 reseptör antagonisti (IL-1Ra) A2 allelinin uzun süreli şiddetli proenflamatuvar bağışıklık cevabıyla ilişkili olabileceği yönünde çalışmalar bulunmaktadır. Ancak, RKKH patogenezinde IL-1Ra varyantının ilişkisi ile ilgili oldukça sınırlıdır. Bu çalışmanın amacı, Türk hasta...

Le Fur et al. (4) claim that INS VNTR subclass ID is responsible for the higher insulin secretion in children previously attributed to the whole class I group. This VNTR (variable number tandem repeat) is a minisatellite locus in the promoter region of INS. For European ancestry, there are long class III and short class I alleles, but class I is rare given African ancestry. Within both classes,...

Context Polymorphism at the insulin gene (INS) VNTR shows variable associations with childhood BMI in different populations. Objective To study INS VNTR associations with body composition and insulin secretion in children. Design Prospective birth cohort study Participants 947 children genotyped for the INS VNTR Main outcome measures Whole body DXA at 9 years to estimate height-corrected fat ma...

Mycobacterium avium subsp. hominissuis (MAH) is an important zoonotic pathogen with raising global health concerns. In humans, MAH is one of the most widespread non-tuberculous mycobacterial species responsible for lung disease. In animals, MAH is frequently isolated from pigs; however, it is also an opportunistic pathogen for other mammals including cattle. To elucidate the genetic diversity o...

Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. DS also present a high risk for early onset of Alzheimer Disease-like dementia. The dopamine (DA) system plays a n...

BACKGROUND Different combinations of variable number of tandem repeat (VNTR) loci have been proposed for genotyping Mycobacterium tuberculosis complex (MTBC). Existing VNTR schemes show different discriminatory capacity among the six human MTBC lineages. Here, we evaluated the discriminatory power of a "customized MIRU12" loci format proposed previously by Comas et al. based on the standard 24 ...