γ-Tocopherol (γT) protects against DNA-damaging effects of nitrogen oxides, yet its physiologic regulation in vivo is unknown. Observational studies indicate inverse associations of 25[OH]-vitamin D with γT and leptin. To determine whether vitamin D(3) supplementation alters levels of lipid-soluble micronutrients, serum samples (N = 85 subjects) from a randomized, double-blind, placebo-controll...

Background & Aims: Immune system abnormalities such as inflammation, increased autoimmunity and the skewed expression of soluble mediators, including cytokines have been observed in autistic patients. The present study aimed to compare the effects of vitamin D supplementation and/or aquatic exercise training on the serum level of inflammatory cytokines, including IL-1β and IL-1RA, and stereotyp...

The discovery of vitamin D as an essential nutrient for skeletal development a century ago was a major public health victory. Supplementation, whether solar or dietary, prevented the devastating eff ects of rickets in chil dren. Five decades later, the molecular mechanisms of the vitamin’s active form (1,25-dihydroxyvitamin D) and its receptor (vitamin D receptor [VDR]), were elucidated, and su...

OBJECTIVES To review the relationships between vitamin D status and systemic lupus erythematosus (SLE) concerning immunological, clinical aspects and possible effects of supplementation in disease modulation. METHODS The literature was reviewed up to January 2017 for studies regarding the epidemiology, pathogenesis, immunological aspects, clinical implications and supplementation strategies. ...

Bachground: Today, some treatments like neurofeedback and Vitamin D Supplementation are of great importance in treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). Present literature showed efficacy each of them. For determination of efficacy of combined treatment, this study aims to compare the efficacy of each of them with combined neurofeedback and vitamin D supplementation in the t...

BACKGROUND Calcium and vitamin D play an essential role in bone metabolism but deficiency and/or inadequate intake are common. OBJECTIVES To describe a practical approach based on the literature regarding clinically important aspects of calcium and vitamin D supplementation. METHODS A systematic evaluation of relevant literature in Medline was conducted. We included physiological studies, p...

OBJECTIVE Vitamin D deficiency is well recognized in selected Middle Eastern countries, but neonatal vitamin D status is not well studied in Jordan and other nearby countries. The aim of this study is to determine the prevalence of vitamin D deficiency in Jordanian newborns and risk factors associated with low levels. METHODS This is a prospective cohort study of newborn infants who were deli...

BACKGROUND To evaluate the effects on serum 25(OH)D and bone mineralization of supplementation of breast-fed Hispanic and non-Hispanic Caucasian infants with vitamin D in infants in Houston, Texas. METHODS We measured cord serum 25(OH)D levels, bone mineral content (BMC), bone mineral density (BMD) and their changes over 3 months of life with 400 IU/day of vitamin D3 supplementation. RESULT...