Forty-one patients with oral lesions and symptoms were enrolled in the study. Their ages ranged from 16 to 79 years with a mean age of 48.5 years. They were divided into two groups. Group I consisted of 25 patients with oral lichen planus and group II consisted of 16 patients with stomatitis or glossitis. Their complete blood counts, hemoglobin typing, serum and red cell folate, and serum vitam...

Measurements of the serum concentrations of the metabolites homocysteine, cystathionine, methylmalonic acid, and 2-methylcitric acid, which accumulates when vitamin B-12-, folate-, and vitamin B-6-dependent enzymatic reactions are impaired, should provide a better indication of intracellular deficiency of these vitamins. We measured the serum concentration of these vitamins and the four metabol...

died) ; and that Michael made excellent attempts to isolate the antiscorbutic principle early in the eighteenth century. Further, Lunin (1881) clearly recognized that small quantities of unknown substances were essential to life, and Pekelharing (1905) demonstrated the existence of diseases due to dietary deficiency. Yet it was Hopkins (1912) who first realized the full significance of vitamins...

V itamin B-12 is a cofactor for 2 enzymes. In the cytoplasm, methionine synthase requires vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine to methi-onine by transfer of a methyl group from methyltet-rahydrofolate. This enzyme links the methylation pathway through synthesis of the methyl donor S-adenosyl methionine and the pathway in which purine and pyrim...

Background: The 25-hydroxyvitamin D3(25-OH D3)deficiency is a common problem worldwide, and it is aprevalent incidence in neonates. Different studies investigated the relationship of vitamin D deficiency with neonatal mortality and morbidity. This study aimed to evaluate the relationship between vitamin D deficiency and respiratory distress in preterm neonates.Methods: A prospective cohor...

BACKGROUND A low circulating vitamin B-6 concentration, which is an independent risk factor for cardiovascular disease, is commonly seen in human inflammation. OBJECTIVE We investigated whether cyclooxygenase inhibitors alter vitamin B-6 metabolism. DESIGN To investigate whether subjects taking a cyclooxygenase inhibitor had an altered vitamin B-6 profile, we conducted a cross-sectional stu...

Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring ...

With great interest, we read the article by Remacha et al (1) in which they discussed a role for homocysteine as a marker for vitamin B-12 status in HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Compared with patients not receiving such therapy, patients receiving HAART not only had higher CD4 and CD8 cell counts and leukocyte counts, they also had higher hemogl...

CONTEXT Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention. OBJECTIVE To evaluate the effect of combined folic acid, vitamin B(6), and vitamin B(12) treatment on cancer risk in women at high risk for cardiovascular disease. DESIGN, SETTING, AND PARTICIPANTS In the Women's Antioxidant and Folic Acid Cardiovascular Study, 5442 US female health p...