may cause peripheral nerve dysfunction suggests that lack of these or other B-complex vitamins may also contribute to neuropathy in the malnourished alcoholic. The present investigation was therefore undertaken to evaluate further the role of aneurin and other B-complex vitamins in the development of this condition. The study consisted of (a) determining circulating levels of aneurin, riboflavi...

Although the structure of thiamin (vitamin B,) has been known for over 40 years (Williams, 1936; Grewe, 1936) and its chemical synthesis accomplished soon thereafter (Williams & Cline, 1936; Andersag & Westphal, 1937; Todd & Bergel, 1937), the biosynthetic pathway to thiamin (3) has still not been elucidated completely. It is well established that the pyrimidine (1) and thiazole (2) moieties ar...

Department of Microbiology and Immunology, Doherty Institute of Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia. Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University, Clayton, Victoria 3800, Australia. Division of Chemistry & Structural Biology, Institute for Molecular ...

Three probable cases of neuropathy in alcoholics are described. They are very atypical for three reasons. First, each developed an acute asymmetrical neuropathy for the first time well after ceasing to drink, and after routine saturation with the vitamin B group. Secondly, none had previously suffered from neuropathy while still drinking. If this puzzling reversal of the usual order of clinical...

BACKGROUND Regular intake of vitamin C/ascorbate reduces blood pressure (BP) in hypertensives. High-dose intravenous vitamin C (IVC) achieves higher plasma levels; however, there is a paucity of research on acute BP effects. Our study is the first to investigate the effect of high-dose IVC, with or without concomitant i.v. nutrients, on BP during i.v. METHODS A cohort of adult patients schedu...

The object of this work is twofold: first, to determine if a diet which contains milk or milk products as the sole source of proteins and vitamins is detrimental to the normal growth impetus of the animal and especially the reproductive function; and second, to determine the value of various levels of wheat embryo as the sole source of vitamin B on growth, reproduetion, and the rearing of the y...

Pangamic acid is shown to be a mixture of variable composition. Criteria of identity and methods of analysis are described for five pharmaceutical dosage forms. Experimental results indicate that the products are not uniform in composition and that composition does not conform to label claims. No satisfactory preclinical drug application for any such preparation has so far been submitted to the...