Canine gastrointestinal infection by Leishmania presenting large bowel involvement has been reported to date. This case series describes two dogs suffering from severe chronic small bowel diarrhea. Duodenal biopsies demonstrated granulomatous infiltration with intracytoplasmatic corpuscles of Leishmania amastigotes. Furthermore one of the dogs was diagnosed with protein-losing enteropathy (PLE)...

toxicity and drug resistance against pentavalent antimonials, medications of choice in treatment of leishmaniasis for more than 5 decades, have become important subjects globally. this study was a randomized, open labeled trial that was designed to determine efficacy and safety of imod as a novel herbal immunomodulator drug for treatment of canine visceral leishmaniasis (cvl).twenty healthy mon...

background: leishmaniasis is a tropical disease that is endemic in some areas of iran, including east azerbaijan . ifn-γ is one of the cytokines that triggers cell-mediated immunity, thus initiating elimination of the infection. this case-control study was performed to investigate the association between the polymorphism of the ifn-γ gene at the +874a/t locus and visceral leishmaniasis (vl). me...

background: although many studies had been conducted on various aspects of canine visceral leishmaniasis (cvl) in domestic dogs in the endemic areas of iran, investigations on cvl in wild canines are rare. methods : this is a cross-sectional study was conducted from december 2012 to 2013 in northeast of iran where human vl is endemic. wild canines were trapped around the areas where human vl ca...

background: dogs have been previously reported to be reservoirs of leishmania infantum as the etiological agent of human visceral leishmaniasis in iran. we report a case of canine visceral leishmaniasis (vl) caused by l. tropica from the north- west of iran where human visceral leishmaniasis is endemic. methods: the canine vl was initially screened by dipstick rk39 and direct agglutination test...

objective: this study aimed to investigate the association between hla alleles and visceral leishmaniasis (vl) in a sample of iraqi patients. methods: a total of 30 patients were studied, in addition to 20 age, gender and ethnicity matched controls. all subjects were genotyped by polymerase chain reaction-sequence specific primers (pcr-ssp) method. results: for hla-class i region (a and b loci)...