George and Wilson [Acta. Cryst. D 50, 361 (1994)] looked at the distribution of values of the second virial coefficient of globular proteins, under the conditions at which they crystallise. They found the values to lie within a fairly narrow range. We have defined a simple model of a generic globular protein. We then generate a set of proteins by picking values for the parameters of the model f...

Protein crystals usually grow at a preferable temperature which is however not known for a new protein. This paper reports a new approach for determination of favorable crystallization temperature, which can be adopted to facilitate the crystallization screening process. By taking advantage of the correlation between the temperature dependence of the second virial coefficient (B(22)) and the so...

2014 The second virial coefficient A2 for a mixture of two monodisperse polymers is studied by means of the renormalization group. It is found that the cross-term A12 has a finite limit if the segment number of one of the polymers tends to infinity. Such behaviour predicts a maximum of A2 in dependence on the relative composition of the polymers. The maximum resulting from our firstorder RG-cal...

The osmotic virial coefficient B2 of globular protein solutions is calculated as a function of added salt concentration at fixed pH by computer simulations of the "primitive model." The salt and counterions as well as a discrete charge pattern on the protein surface are explicitly incorporated. For parameters roughly corresponding to lysozyme, we find that B2 first decreases with added salt con...

Interactions between proteins are often sufficiently weak that their study through the use of conventional structural techniques becomes problematic. Of the few techniques capable of providing experimental measures of weak protein-protein interactions, perhaps the most useful is the second virial coefficient, B(22), which quantifies a protein solution's deviations from ideal behavior. It has lo...

Abstract The cross second virial coefficient $$B_{12}$$ B 12 for the interaction between water (H 2 O) and carbon monoxide (CO) was obtained with low uncertainty at temperatures from 200 K to 2000 employing a new intermolecular potential energy surface (PES) H O–CO syst...

We consider a mixture of two single-spin-state fermions with an interaction of negligible range and infinite s-wave scattering length. By varying the mass ratio α across αc ≃ 13.6069 one can switch on-and-off the Efimov effect. We determine analytically the third cluster coefficient of the gas. We show that it is a smooth function of α across αc since, unexpectedly, the three-body parameter cha...

A relationship between the osmotic second virial coefficient of proteins in aqueous salt solutions, the solubility of proteins in these solutions and the salt concentration is presented. The model developed considers that the solid-liquid equilibrium is established with neutral protein molecules and that the relationship between the protein solubility and the salt concentration follows Cohn's e...