BACKGROUND Antiretroviral treatments decrease HIV mother-to-child transmission through pre/post exposure prophylaxis and reduction of maternal viral load. We modeled in-utero and intra-partum HIV transmissions to investigate the preventive role of various antiretroviral treatments interventions. METHODS We analysed data from 3,759 women-infant pairs enrolled in 3 randomized clinical trials ev...

Nonhuman primate models are needed for evaluations of proposed strategies targeting residual virus that persists in HIV-1-infected individuals receiving suppressive combination antiretroviral therapy (cART). However, relevant nonhuman primate (NHP) models of cART-mediated suppression have proven challenging to develop. We used a novel three-class, six-drug cART regimen to achieve durable 4.0- t...

The coronavirus disease-2019(COVID-19) was reported in Wuhan, China, in late December 2019 and soon became the most serious global health challenge due to high rate of human-to-human transmission. The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), is a single-stranded RNA virus and belongs to the large Coronaviridae family. Paclitaxel, an antineoplastic drug extracted from the Tax...

Background and Aims: Medicinal plants possess a variety of beneficial characteristics without causing substantial adverse effects. Antimicrobial activity is one of the qualities, among many others, that have been identified. Althaea officinalis is an annual plant belonging to the Malvaceae family with therapeutic qualities in both the leaves and the roots. Specifically, the effects of Althaea o...

Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there is an urgent need to develop therapies to reduce rates of HCV infection of transplanted livers. Approved therapeutics for HCV are poorly tolerated and are of limited efficacy in this patient population. Human monoclonal antibody HCV1 recognizes a highly-conserved linear epitope of the HCV E2 envelope glycopr...

Many viruses within the Flavivirus genus cause significant disease in humans; however, effective antivirals against these viruses are not currently available. We have previously shown that a thiopurine drug, 6-methylmercaptopurine riboside (6MMPr), inhibits replication of distantly related viruses within the Flaviviridae family in cell culture, including bovine viral diarrhea virus and hepatiti...

background: to suggest south india ct diagnostic reference levels (drls) by collecting radiation doses for the most commonly performed ct examinations. materials and methods: a pilot study investigated the most frequent ct examinations. 110 ct sites were asked to complete a survey booklet to allow the recording of ct parameters for each of 3 ct examinations during a 1 year time period. dose dat...

Objective: Indonesian health workers mostly received three doses of vaccine, using two inactivated viral vaccines, followed by the mRNA vaccine platform for third dose. This study was conducted to investigate and compare side effects vaccines workers. Methods: Cross-sectional on who COVID-19 completely willing follow research. Data collected were demographic characteristics, previous disease hi...

The effect of various doses of 3-methylcholanthrene on s.c. tumor induction and the occurrence of the murine C-type RNA group specific (gs) viral antigen in tumor tissue were studied in weanling mice of 8 genotypically different strains. Tumor incidence was found to be related to the dose of 3-methylcholanthrene. On the other hand, the incidence of gs antigen in the induced tumors was independe...

A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional envelope-type nano device (R8-MEND). We measured the nuclear delivery of pDNA to distinguish the non-linearity in intracellular pharmacokinetics or pharmacodynamics after transfection with R8-MEND at di...