Several biological medicines derived from human and animal plasmas can effectively improve haemostasis in individuals with inherited or acquired defects in haemostasis. Factor VIII and factor VIII/vWF and factor IX concentrates are used to treat haemophilia A, von Willebrand disease and hemophilia B respectively. Cryoprecipitates are used to treat hypofibrinogenemia and von Willebrand disease w...

Correspondence to: Dr. Anna Pavlova Institut für Experimentelle Hämatologie und Transfusionsmedizin , Universitätsklinikum Bonn Sigmund-Freud-Str. 25, 53127 Bonn, Germany Tel. +49/(0)/228/28 71 97 11, Fax +49/(0)228/28 71 60 87 E-mail: [email protected] Hämostaseologie 2010; 30 (Suppl 1): S153–S155 Human blood coagulation factor VIII (FVIII) is an essential protein for the blood coag...

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Introduction Factor dosages are part of the diagnostic work up in patients with bleeding tendency (factor (F) VIII and FIX) or in thrombophilia screening (FVIII). The correct diagnosis of FVIII and FIX deficiency and the assessment of severity of the disease are essential for a patient-tailored treatment strategy. Persistently high levels of FVIII are regarded as a thrombophilia risk marker. FV...

Haemophilia A is a rare genetic condition leading to coagulation factor VIII deficiency and thus predisposing to bleeding diathesis. Due to advances in treatment, life expectancy of haemophilia A sufferers is increasing, and the incidence and prevalence of coronary artery disease are rising. There have been many reported cases of acute myocardial infarction in such patients, who subsequently un...

A 40-year-old man was complaining of severe left ocular pain and headache for the past 2 months. His left eye was traumatized and rendered blind about 20 years ago. He had no other medical problems and his preoperative laboratory tests were nonspecific. Evisceration of the left eye was performed for pain control and cosmetic improvement. However, postoperative progressive and prolonged eyelid s...

Hemophilic pseudotumor is a term used to describe a progressive, encapsulated, slowly expanding, cystic mass occurring as a result of recurrent hemorrhage, usually in soft tissues but occasionally in bone or subperiosteal location. It is an uncommon but serious complication of bleeding diathesis occurring in only 1 2% cases and has mostly been reported in severe factor VIII and IX deficiency. W...

A rare case of Acute lymphoblastic leukemia with hemophillia in a 12 year old boy is presented in the article. Patient was known case of hemophillia (factor VIII deficiency). He was diagnosed as a case of ALL based on bone marrow examination and immunophenotypic study. Patient was treated as per Children Cancer group guidelines. The main aim of reporting this rare association lies in developing...

In This Issue: • NovoSeven • Therapeutic Interchanges Introduction: Recombinant human activated Factor VII (rFVIIa), or NovoSeven, is a hemostatic agent which is structurally similar to human plasma-derived coagulation Factor VIIa. Recombinant FVIIa is currently licensed by the US Food and Drug Administration (FDA) in patients with hemophilia A or B with inhibitors to Factor VIII or Factor IX o...

background: hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors viii (hemophilia a) or ix (hemophilia b) in plasma. we aimed to identify patients with hemophilia in kermanshah, iran and assess the incidence of inhibitors in this population and its associated factors. methods: this study was conducted on patients with hemophilia a and b ...