Abstract The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, metabolomics to a panel isogenic K13 mutant or wild-type P. lines, we provide evidence that alter multiple aspects parasite’s int...

Eight samples of accessory sex glands donkey were used to compare between the immature and mature donkey. The morphological parameters involved position, relation, shape, length, width, weight each gland. results in ampulla ductus deferens spindle shape strcture ends part deferens, located dorsaly urinary bladder opened into ejaculatory duct, measured 1.85±0.04cm, 3.81±0.18mm 0.96±0.02g 7.57±0....

Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions. For example, astrocytes that reside near the ventral surface of the brainstem (central respiratory chemosensitive area) respond to physiological decreases in pH with vigorous elevations in intr...

This paper presents the results of a feasibility study of potential wind energy developments on the islands of New England. The study included the compilation of an inventory of New England coastal islands, a categorization of the islands according to energy related criteria, and an overview of the current energy supply situation on those islands where energy demanding activities take place. Th...

background: the rapid increase of hiv-1 strains resistant to current antiretroviral drugs is a challenge for successful aids therapy. this necessitates the development of novel drugs, and to this end, availability of screening systems for in vitro drug discovery is a priority. herein, we report the modification of a previously developed system for increased sensitivity, ease of use, and cost-ef...

Recent experiments indicate that modification of synaptic strength may involve rapid regulation of vesicular traffic on the postsynaptic side of the synapse. The specific vesicular trafficking route taken by postsynaptic receptors appears to depend on the stimulus.

Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric conditions. Here, we report a novel mouse model of enhanced vesicular function via bacterial artificial chromosome (BAC)-mediated overexpression of the vesicular monoamine transporter 2 (VMAT2; Slc18a2). A twofold increase in vesicular transpo...

kuh-e-siah is located in the north of gavkhuni lagoon and east of the varzaneh (se of isfahan) and is a part of urumieh-dokhtar magmatic arc (udma). the volcanic rocks of this area are vesicular basalt and basaltic andesite with late miocene age. the most common textures of these rocks are porphyry, microlitic porphyritic, hyaloporphyric and vesicular. plagioclase, olivine and clinopyroxene are...

Repeated high-dose injections of methamphetamine (METH) rapidly decrease dopamine uptake by the vesicular monoamine transporter-2 (VMAT-2) associated with dopaminergic nerve terminals, as assessed in nonmembrane-associated vesicles purified from striata of treated rats. The purpose of this study was to determine whether METH similarly affects vesicular uptake in the hippocampus; a region innerv...