نتایج جستجو برای: verotoxin

تعداد نتایج: 354  

Journal: :Infection and immunity 1996
J Fujii Y Kinoshita T Kita A Higure T Takeda N Tanaka S Yoshida

When rabbits were given intravenously purified verotoxin 2 (VT2) at 5 microg/kg of body weight, they developed hemorrhagic diarrhea, flaccid paresis, an ataxic gait, an opisthotonic posture, and convulsions. To examine the effects of VT2 toxemia on the rabbit central nervous system, magnetic resonance imaging and ultrastructural studies were performed. At 24, 57, and 80 h after injection of VT2...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 1997
Dana J Philpott Cameron A Ackerley Amanda J Kiliaan Mohamed A Karmali Mary H Perdue Philip M Sherman

Verotoxin-producing Escherichia coli (VTEC) are pathogenic bacteria associated with diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Verotoxins (VTs) elaborated by these organisms produce cytopathic effects on a restricted number of cell types, including endothelial cells lining the microvasculature of the bowel and the kidney. Because human intestinal epithelial cells lack the glo...

Journal: :Infection and immunity 1997
D J Bast J L Brunton M A Karmali S E Richardson

The verotoxins (VT1 and VT2), produced by strains of enterohemorrhagic Escherichia coli, have been implicated in the pathogenesis of hemorrhagic colitis and the hemolytic uremic syndrome. To better understand the role of globotriaosylceramide (Gb3) receptor binding by the verotoxins in disease production, we examined the clinicopathologic effects of an intravenously (i.v.) administered verotoxi...

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