random monoallelic expression. Thus, the hypothesis of non-Mendelian inheritance remains valid, and the search for other mechanisms ensues. They do not exclude a complex situation in which both Mendelian and non-Mendelian mechanisms are at play. In the clinical part of this special issue, thyroid disorders associated with well-known genetic syndromes are carefully analyzed and reviewed. First, ...

ohtahara syndrome or ealy infantile epileptic encephalopathy is a rare cause of epileptic seizures during infancy and represents the earliest type of age related symptomatic generalized epilepsies. the main etiologic factor associated with ohtahara syndrome is cerebran dysgenesis. this case was the product of in vitro fertilization (ivf) after 18 years of infertility . neuroimaging findings con...