Coronary arteriosystemic fistula which drains into the left ventricular cavity is a rare congenital anomaly. A case of double fistulae between the left anterior descending and left circumflex coronary arteries and left ventricular cavity is presented. The patient's chief complaint, chest pain, was attributable to the "steal phenomenon."

Passive ventricular remodeling is defined by the process of molecular ventricular adaptation to different forms of cardiac pathophysiology. It includes changes in tissue architecture, such as hypertrophy, fiber disarray, alterations in cell size and fibrosis. Besides that, it also includes molecular remodeling of gap junctions, especially those composed by Connexin43 proteins (Cx43) in the vent...

Conventional therapies for myocardial infarction attenuate disease progression without contributing significantly to repair. Because of the capacity for de novo cardiogenesis, embryonic stem cells are considered a potential source for myocardial regeneration, yet limited information is available on their ultimate therapeutic value. We treated infarcted rat hearts with CGR8 embryonic stem cells ...

background: the cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. this study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. methods: five groups (7 each) of male sprague-dawley rats, including a control group, a diabetes (induced by streptozocin and nicotinamide)...

Introduction: The aim of the study was to investigate the structural and hemodynamic changes as well as cardiac transcriptional profile of the key regulatory proteins, sirtuins family (SIRT1-7), in adaptive and mal-adaptive phases of left ventricular hypertrophy (LVH). Methods: LVH was induced in male Wistar rats (190±20g) by abdominal aortic banding. The third and sixteenth weeks post-surgery ...

purpose: the aim of this study was to investigate the feasibility and effectiveness of endoscopic neurosurgery for patients with third ventricular colloid cysts without ventriculomegaly. methods: seventy-one patients with third ventricular colloid cysts were identified and recruited to this study. eighteen of these patients did not have concomitant hydrocephalus and underwent primary endoscopic...

the left ventricular aneurysm is one of the most significant complications of myocardial infarction and is defined as the expansion of the ventricular wall. the coronary artery aneurysm is characterized by an abnormal dilation of the localized portion of the coronary artery, and its main cause is atherosclerosis. we herein report an unusual case of coronary artery and left ventricular aneurysms...

OBJECTIVE The aim was to measure changes in the numbers and size of ventricular myocytes in human hearts with marked ventricular hypertrophy and no clear signs of cardiac failure, to determine whether myocyte cellular hypertrophy is the only factor involved in the increase in cardiac mass. METHODS Morphometric techniques were applied to estimate the number of myocyte nuclei per unit volume of...

Determination of the copper (Cu) content of rat, rabbit, and mouse hearts proved to be a sensitive microassay for mitochondria] content and membrane area of mitochondrial cristae per unit myocardial cell volume. The direction of variations in Cu content correlated well with variations in membrane area of mitochondrial cristae determined by morphometry of electron micrographs during normal postn...

Overexpression of -catenin, a protein that functions in both cell adhesion and signaling, causes expansion of the cerebral cortical precursor population and cortical surface area enlargement. Here, we find that focal elimination of -catenin from cortical neural precursors in vivo causes premature neuronal differentiation. Precursors within the cerebral cortical ventricular zone exhibit robust -...