tehran is located in a valley at the foot of the alborz mountains in northern iran (35 degrees latitude north). urban expansion in tehran resulted from a high rate of population growth and rural-urban migration combined with a strong tradition of centralization in the capital. airborne particulate of tehran's atmosphere was fractionated in a 6-stage high-volume cascade impactor. the first ...

When increased in vascular tissues, angiotensin-converting enzyme 2 (ACE2), a carboxypeptidase that hydrolyzes angiotensin II to angiotensin-(1-7), may augment the growth inhibitory and vasodilatory effects of the heptapeptide. We investigated the regulation of ACE2 and angiotensin-(1-7) expression in aortas and carotid arteries of 12-wk-old male spontaneously hypertensive rats (SHR) by determi...

In thick ascending limbs (THALs), nitric oxide (NO) decreases NaCl reabsorption via cGMP-mediated inhibition of Na-K-2Cl cotransporter (NKCC2). In angiotensin (ANG II)-induced hypertension, endothelin-1 (ET-1)-induced NO production by THALs is impaired. However, whether this alters NO's natriuretic effects and the mechanisms involved are unknown. In other cell types, ANG II augments phosphodies...

BACKGROUND Imiquimod is currently approved for the treatment of genital warts and has been shown to decrease recurrences of genital herpes in the guinea pig model of genital herpes. Therefore, we evaluated the safety and potential of topical imiquimod to decrease the rate of recurrence in humans with a history of recurrent herpes labialis. METHODS Forty-seven subjects with recurrent herpes la...

OBJECTIVE Study the impact of intra-articular interleukin-1 receptor antagonist (IL-1 ra) treatment on lubricin biosynthesis following anterior cruciate ligament transection (ACLT) in the rat and evaluate the effect of combined IL-1 ra and recombinant human lubricin (rhPRG4) treatments on chondrocyte apoptosis. METHODS ACLT was performed in male Lewis rats. Treatments included IL-1 ra or vehi...

AIMS We analysed the chronic effects of the peroxisome proliferator-activated receptor β/δ (PPAR-β) agonist GW0742 on the renin-independent hypertension induced by deoxycorticosterone acetate (DOCA)-salt. METHODS AND RESULTS Rats were treated for 5 weeks with: control-vehicle, control-GW0742 (5 or 20 mg kg(-1) day(-1)), DOCA-vehicle, DOCA-GW0742 (5 or 20 mg kg(-1) day(-1)), DOCA-GSK0660 (1 mg...

improvement in braking performance and vehicle stability can be achieved through the use of braking systems whose brake force distribution is variable. electronic braking force distribution has an important and serious role in the vehicle stopping distance and stability. in this paper a new approach will be presented to achieve the braking force distribution strategy for articulated vehicles. f...

The single vehicle routing problem with multiple routes is a variant of the vehicle routing problem where the vehicle can be dispatched to several routes during its workday to serve a number of customers. In this paper we propose a goal programming model for multi-objective single vehicle routing problem with time windows and multiple routes. To solve the model, we present a heuristic method wh...