Adaptation to stress is a basic phenomenon in mammalian life that is mandatorily associated with the activity of the hypothalamic-pituitary-adrenal (HPA) axis. An increased resting activity of the HPA axis can be measured during pregnancy and lactation, suggesting that these reproductive states lead to chronic load in females. In this study, we examined the consequences of the congenital lack o...

On a daily basis, practising nephrologists evaluate hyponatremic or, on the opposite side, polyuric states using physio-pathological concepts related to central vasopressin secretion and water conservation by the kidneys. The purpose of this review is to highlight new basic and clinical developments describing the hypothalamic release and peripheral renal actions of the antidiuretic hormone, ar...

Arginine vasopressin is elevated in congestive heart failure. To determine the efrect of arginine vasopressin upon systemic hemodynamics and regional blood flows, we administered the specific inhibitor of the vascular action of vasopressin [1-(p-mercapto-f,i3-cyclopentamethylenepropionic acid),2-(0-methyl)-tyrosine]-arginine vasopressin [d(CH2)5Tyr(Me)AVP] to 15 dogs with chronic right-heart fa...

Vasopressin (antidiuretic hormone) is emerging as a potentially major advance in the treatment of septic shock. Terlipressin (tricyl-lysine-vasopressin) is the synthetic, long-acting analogue of vasopressin, and has comparable pharmacodynamic but different pharmacokinetic properties. Vasopressin mediates vasoconstriction via V1 receptor activation on vascular smooth muscle. Septic shock first c...

OBJECTIVE To compare vasopressin and adrenaline in the treatment of patients with cardiac arrest presenting to or in the Emergency Department (ED). DESIGN A randomised, double-blind, multi-centre, parallel-design clinical trial in four adult hospitals. METHOD Eligible cardiac arrest patients (confirmed by the absence of pulse, unresponsiveness and apnea) aged >16 (aged>21 for one hospital) ...

This study compares the effect of arginine-vasopressin with phenylephrine on arterial pressure, heart rate, and renal sympathetic nerve activity in conscious rabbits with and without functional arterial baroreflexes and in rabbits with lesions of the area postrema. In intact rabbits, progressive infusions of arginine-vasopressin result in large decreases in renal sympathetic nerve activity and ...

Elevation of brain catecholamine levels by systemic administration of L-dopa in dogs pretreated with the dopa decarboxylase inhibitor carbidopa inhibits the secretion of vasopressin and adrenocorticotropic hormone (ACTH) and decreases arterial blood pressure. The aim of the present study was to determine whether the inhibition of vasopressin secretion is mediated by dopamine or norepinephrine, ...

The arginine vasopressin and oxytocin content of normal and cancerous human breast tissue were measured using radioimmunoassay. Both peptides were present in amounts greater than that found in the circulation, but no difference between normal and malignant tissues was found. Binding of [3H]oxytocin and [3H]vasopressin were characterized in human breast carcinoma cells (MCF7 cells). Binding of b...

We have suggested in preliminary publications" 2 that the antidiuretic action of vasopressin in the mammalian kidney may depend on a sulfhydryl-disulfide interchange involving SH groups on the receptor and the S-S bridge of the hormone. Strong support for this concept is presented in the preceding paper' where it is shown that the vasopressin-induced increase in the permeability of a simple liv...

heart failure (hf) is still a major problem worldwide with high morbidity and mortality rates. the recently developed medication for hf is still incapable of reducing its morbidity and mortality, and clinical data supporting the efficacy and safety of its mainstay therapy remain insufficient. arginine-vasopressin (avp) plays important roles in circulatory and water homeostasis, one of which is ...