Age-related vascular diseases are induced by vascular dysfunction, which involves changes in the vasomotor response. The voltage-dependent L-type calcium channel (VDCC) protein is involved in the regulation of vessel function (contraction/relaxation action). In the present study, we evaluated age-related vasomotor function and expression of the signal-related target proteins, including VDCC, us...

BACKGROUND Determining symptoms of menopause in older users of hormonal injectable contraceptives may be challenging, owing to method-induced amenorrhoea, suppression of follicle-stimulating hormone (FSH) and vasomotor symptoms. OBJECTIVE To investigate menopausal symptoms in women aged 40 - 49 using injectable contraceptives depot-medroxyprogesterone acetate (DMPA), norethisterone enanthate ...

BACKGROUND AND PURPOSE During diabetes, expression of inducible nitric oxide synthase (iNOS) plays an important role in the development of endothelial dysfunction in extracranial blood vessels. Progression of vascular dysfunction after the onset of diabetes differs among vascular beds. In this study, the effects of hyperglycemia/diabetes on vasomotor function were examined in cerebral arteriole...

Neurogenic Control of Cerebral Blood Flow in the Baboon. Effects of Alpha Adrenergic Blockade With Phenoxybenzamine on Cerebral Autoregulation and Vasomotor Reactivity to Changes in Paco2 • Cerebral autoregulation was studied in the baboon by increasing and decreasing cerebral perfusion pressure (CPP) before and after intravenous administration (1..5 mg per kilogram) of a long-acting alpha adre...

BACKGROUND AND PURPOSE The aim of this trial was to evaluate the effectiveness of extracranial-intracranial bypass with respect to vasomotor reactivity in patients with internal carotid artery occlusions and absent vasomotor reactivity, comparing them with a control group treated conservatively. METHODS To test vasomotor reactivity in 104 patients with unilateral occlusion of the internal car...

IT IS worthwhile noting at the outset that this controversy is not new, the topic having been debated with vigor for the past 100 years or so. What has changed is the way in which the question at issue has been posed. In earlier experiments, the question was whether or not vasomotor nerves existed; but once they had been demonstrated, the problem was to assign a functional role to them. By the ...

OBJECTIVE To evaluate sexual function in midlife women using selective serotonin reuptake inhibitors for vasomotor symptoms. Selective serotonin reuptake inhibitors effectively treat vasomotor symptoms but adversely affect sexual function in depressed populations. Information on sexual function in nondepressed midlife women using selective serotonin reuptake inhibitors for vasomotor symptoms is...

This article reviews the innervation of the arterial system of the lower extremity, lumbar sympathectomy in vascular surgery, lumbar sympathectomy for digital gangrene and in the prevention of major amputation of the lower extremity and substance P's role in neurogenic inflammatory modulation. Long-term results of lumbar sympathectomy and direct arterial bypass surgery have also been reviewed. ...

BACKGROUND Vasomotor symptoms such as hot flashes and night sweats are a common concern of perimenopausal and postmenopausal women and are associated with a decreased quality of life. These symptoms can be effectively managed with hormone therapy, but safety concerns limit its use. Thus, understanding the effectiveness of nonpharmacologic therapies such as acupuncture or yoga is critical to man...

During the menopausal transition, women frequently develop vasomotor symptoms. However, unpleasant symptoms may accompany this which can have a severe influence on daily functioning and overall quality of life. This article discusses cognitive behavioural therapy (CBT) for suffering from such as worry, stress, poor mood, hot flushes, night sweats, well how thoughts, physical symptoms, behaviour...