First web space contracture causes significant morbidity and hence their release is important to make use of normal hand functions. helps in improving the grasp. There are several methods normalizing 1st webspace. In this article we describing a local flap that uses spare tissue thumb polydactyly for recovering defect created from first contracture, thereby providing coverage with has good vasc...

Eyelash area and eyelid marginal defects can be quite problematic to reconstruct in case of deficiency due its unique features. Reconstruction eyelashes not only contributes aesthetic but also functional results. The switch flap technique, which aims two stages, provide a tissue with reliable vascularity. Besides, the main advantage technique is reconstruction their exact equivalents ability pr...

PURPOSE For many vascular diseases, aging appears to be an independent risk factor for severity of vascular complications, and blood vessels of aged individuals often demonstrate exaggerated repair responses to injury. This study was undertaken to determine the influence of aging on the severity of neovascularization in a mouse model of laser-induced choroidal neovascularization (CNV). METHOD...

Skin flap vascularity is a critical determinant of aesthetic results in autologous ear reconstruction. In this study, we investigate the use of intraoperative laser-assisted indocyanine green angiography (ICGA) as an adjunctive measure of skin flap vascularity in pediatric autologous ear reconstruction. Twenty-one consecutive pediatric patients undergoing first-stage autologous total ear recons...

Inhibition of platelet derived growth factor (PDGF) can increase the efficacy of other cancer therapeutics, but the cellular mechanism is incompletely understood. We examined the cellular effects on tumor vasculature of a novel DNA oligonucleotide aptamer (AX102) that selectively binds PDGF-B. Treatment with AX102 led to progressive reduction of pericytes, identified by PDGF receptor beta, NG2,...

Stromal vascularity is thought to be a major factor involved in the progression of carcinoma. However, the crucial mechanisms of vascularization in the stroma are not well understood. Vascularity could be regulated by various cytokines produced by neoplastic or stromal cells in carcinoma. Thrombospondin (TSP) has an inhibitory role against vascularization in vitro, although the biological signi...

OBJECTIVE To undertake an observational study to see whether first trimester placental vascularity, measured with a standardized power Doppler index: 3D-FMBV, is different in pregnancies which either develop pre-eclampsia or lead to term, normotensive small for gestational age (SGA) babies. METHODS Women were scanned between 11 and 13+6 weeks. The placental volume (sPlaV) was estimated using ...