Hemangiopericytomas are uncommon neoplasms of vascular origin that mostly arise from extremities, retroperitoneum, and pelvic fossa. They are rarely found in the parotid gland. A 35-year-old female patient presented with a swelling in the right preauricular region. Fine-needle aspiration biopsy performed twice yielded an extraordinary amount of blood. A cytological diagnosis could not be made. ...

Common causes of lower gastrointestinal bleeding include diverticular disease, vascular disease, inflammatory bowel disease, neoplasms, and hemorrhoids. Lower gastrointestinal bleeding of appendiceal origin is extremely rare. We report a case of lower gastrointestinal bleeding due to angiodysplasia of the appendix. A 72-year-old man presented with hematochezia. Colonoscopy showed active bleedin...

Idiopathic sudden hearing loss (ISHL) is defined as a sensorineural hearing loss of 30 dB or more at least three contiguous frequencies, which develops over a period of a few hours to 72 hours . Its incidence is 520/100.000 or 4,000 new cases per one year . Almost 98% of the patients are affected unilaterally . Although viral infections, vascular disorders, rupture of cochlear membranes, immuno...

Intraosseous vascular lesions are rare conditions, comprising only 0.5 to 1% of all intraosseous hemangioma tumors. They mainly occur in the second decade of life especially in female. The most common locations are the vertebral column and skull; nevertheless, the mandible is quite rare location. Hemangiomas are benign vasoformative neoplasms of endothelial origin. However, the origin of centra...

IMPORTANCE Inhibition of angiogenesis is an effective anticancer strategy because neoplasms require a rich blood supply. Ramucirumab, approved by the US Food and Drug Administration in 2014 to treat gastric adenocarcinomas and non-small cell lung carcinomas, targets vascular endothelial growth factor 2 (VEGFR2). We identified a patient prescribed a regimen of irinotecan hydrochloride, cetuximab...

Background Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunoh...

1. Smith NP,Wilson Jones E. Multinucleate cell angiohistiocytoma: a new entity. Br J Dermatol. 1985;113:15. 2. Monteagudo B, Labandeira J, Ginarte M, Álvarez JC, De las Heras C, Cacharrón JM, et al. Multinucleate cell angiohistiocytoma. Actas Dermosiiliogr. 2005;96:272-3. 3. Chang SN, Kim HS, Kim SC, Yang WI. Generalized multinucleate cell angiohistiocytoma. J Am Acad Dermatol. 1996;35:320-2. 4...

Abstract The Notch pathway is a major regulator of endothelial transcriptional specification. Targeting the receptors or Delta-like ligand 4 (Dll4) dysregulates angiogenesis. Here, by analyzing single and compound genetic mutants for all signaling members, we find significant differences in way ligands regulate liver vascular homeostasis. Loss caused hypermitogenic cell-cycle arrest senescence....

Skeletal muscle is remarkably free of neoplasms despite its great body mass. Metastatic tumors to skeletal muscle are distinctly uncommon. Primary myogenous tumors (defined as those whose cytoplasm contains myofibrils) are infrequent, compared to primary lesions of supporting stroma and vascular origin. Almost all non-myogenic tumors of striated muscle occur also in other areas of the body and ...

Livedoid vasculopathy (LV) is a chronic and recurrent disease consisting of livedo reticularis and symmetric ulcerations, primarily located on the lower extremities, which heal slowly and leave an atrophic white scar ("atrophie blanche"). Neurological involvment is rare and presumed to be secondary to the ischemia from vascular thrombosis of the vasa nervorum. Laboratory evaluation is needed to...