BACKGROUND Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following study tested the hypothesis that dysregulation of nestin expression in vascular smooth muscle cell...

Disordered neovascularization and impaired wound healing are important contributors to diabetic vascular complications. We recently showed that high-density lipoproteins (HDLs) enhance ischemia-mediated neovascularization, and mounting evidence suggests HDL have antidiabetic properties. We therefore hypothesized that HDL rescue diabetes-impaired neovascularization. Streptozotocin-induced diabet...

The current study describes new, antivascular, and antitumor effects of human endostatin. A novel system for continuous, localized delivery of antiangiogenic compounds to brain tumors was used. The delivery system was composed of endostatin-producing 293 cells encapsulated into immuno-isolating sodium alginate. Intravital multifluorescence microscopy was used to assess vascular and antitumor ef...

BACKGROUND: Diabetes mellitus is a chronic metabolic disorder, affected by fructose, and artificial sweeteners. Aspartame fructose are popularly used, diabetics, as substitutes to glucose. AIM: This study evaluated the effect of high aspartame on vascular reactivity, glucose, hepatic metabolism in diabetic rats. MATERIALS AND METHODS: Forty-eight male rats were divided into six groups: Control,...

Background& Objective: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment  and appears to be capable to distinguish between malignant neo-vasculature and normal vesse...

conclusions this rare observation supports the role of immunosuppressive therapy in preventing the recurrence of life-threatening vascular lesions in the management of behcet’s disease. introduction arterial involvement in behcet’s disease has been previously described. we report a rare case of a large and long-segment thoracoabdominal aneurysm, which was associated with behcet’s disease and ha...

arteriovenous fistulae traditionally have been placed in the upper extremity. experience with groin hemodialysis access has been discouraging because of high infection rates and associated limb amputation. the aim of this study was to determine infection rates, patency rates, and possible predictive factors for prosthetic thigh angioaccess outcomes in our hemodialysis patient population. a pros...

results 22 patients were male (73.3%) and the mean age was 60.3 ± 10.6 years in our study group. the most common artery for cut off and run off was superior femoral artery in both assessments. proximal section of each artery was the most common anatomical section for cut off and run off. there was a same report of cut off artery by mr-angiography and surgery (kappa coefficient of agreement was ...

by increasing number of vessels. salivary gland tumors are uncommon and their overall incidence is about 3 per 100000 per year. salivary gland hemangioma makes up 1 % of all salivary gland tumors. trismus resulting from parotid hemangioma is so rare. the patient was a 6-month-old boy with a huge lesion in his right parotid who referred to shahid sadoughi hospital of yazd, iran. the lesion appea...

Objective(s): Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alanyl (Ala-GLN) on random skin flaps survival in rats.Materials and Methods: Dorsal skin flaps with c...