Objective To investigate the diagnostic value of subtests of the NEUROPSI battery for differentiating subcortical vascular dementia (SVaD) from Alzheimer's disease (AD). Methods Thirteen patients with mild SVaD, 15 patients with mild probable AD, and 30 healthy controls, matched for age, education and dementia severity (in the case of patients), were submitted to the Mini-Mental State Examina...

The world’s population is aging, life expectancy increasing in the past century as result of improvements healthcare and people arrive to live longer healthier. However, this has also resulted increase number with age-related diseases like most dementia etiologies (fundamentally Alzheimer Vascular dementia). growth next 20 years will be exponential around world but even more those countries Low...

BACKGROUND We explored the efficacy and tolerability of rivastigmine among Chinese patients with subcortical vascular dementia. METHODS Forty subjects were randomized to either placebo (n = 20) or rivastigmine (n = 20) in a double-blind 26-week trial. Outcome measures were cognition (mini-mental state examination, frontal assessment battery), neuropsychiatric inventory (NPI), instrumental act...

BACKGROUND Exposure to ambient air pollution is suspected to cause cognitive effects, but a prospective cohort is needed to study exposure to air pollution at the home address and the incidence of dementia. OBJECTIVES We aimed to assess the association between long-term exposure to traffic-related air pollution and dementia incidence in a major city in northern Sweden. METHODS Data on demen...

BACKGROUND AND PURPOSE We sought to determine the predictive value of magnetic resonance imaging measures of vascular disease (white matter hyperintensities [WMHs], lacunes, microbleeds, and infarcts) compared with atrophy on the progression of mild cognitive impairment to dementia. METHODS We included 152 consecutive patients with mild cognitive impairment. Baseline magnetic resonance imagin...

BACKGROUND Risk factors for dementia can be divided into those that lead to pathologic insults and those that render the brain more vulnerable to such insults. Dementia prevention strategies need to be informed as to whether to prioritize reducing risk of pathology or to reduce the vulnerability of the brain to pathologic insult. Lower premorbid cognitive ability is associated with both increas...

The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive ...

BACKGROUND Vascular cognitive impairment (VCI), compared to vascular dementia (VD), has a broader definition and highlights the effect of vascular disease in dementia, and stroke seems play an important role in the development of VCI. However, not all patients with brain infarcts suffer from VCI; unique risk factors appear to cause such progression. This study aimed to find potential risk facto...

Context. The relation between plasma lipids, Alzheimer’s disease and vascular dementia, and the impact of lipid lowering drugs remains unclear. Objective. To investigate the relation between plasma lipid levels and the risk of Alzheimer’s disease and vascular dementia, and the impact of lipid lowering drugs on this relationship. Design and Setting. Cross-sectional and prospective community-base...

BACKGROUND AND PURPOSE The present study was designed to detect the abnormalities of the cerebral grey-matter density in subcortical ischemic vascular dementia patients by FSL-VBM method to promote the early diagnosis of it. METHODS Nine subcortical ischemic vascular dementia patients and nine age-matched normal controls underwent MRI brain structure scanning that was performed on a SIEMENS A...