introduction: alzheimer’s disease (ad) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (aβ) deposition and neuronal dysfunction leading to impaired learning and recall. among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. methods: in the present study, effects of the intracerebroventricularly administration of an ...

BACKGROUND Tobacco smoking remains the leading modifiable health hazard and varenicline is amongst the most popular pharmacological options for smoking cessation. The purpose of this study is to critically evaluate the extent of gastrointestinal adverse effects of varenicline when used at maintenance dose (1 mg twice a day) for smoking cessation. METHODS We conducted a meta-analysis of random...

BACKGROUND Smoking cessation services are available in England to provide assistance to those wishing to quit smoking. Data from one such service were analysed in order to investigate differences in quit rate between males and females prescribed with different treatments. METHODS A logistic regression model was fitted to the data using the binary response of self-reported quit (failed attempt...

Background Ensuring adherence to prescribed smoking cessation medications, such as Champix® (varenicline), is essential during a quit attempt as non-adherence can significantly reduce the likelihood of achieving prolonged smoking abstinence. The use of dose administration aids may improve adherence, though medication stability on repackaging is not guaranteed, due to a lack of available data fr...

BACKGROUND Stopping smoking is associated with many important improvements in health and quality of life. The use of cessation medications is recommended to increase the likelihood of quitting. However, there is historical and renewed concern that smoking cessation therapies may increase the risk of cardiovascular disease events associated within the quitting period. We aimed to examine whether...

BACKGROUND Varenicline and bupropion, efficacious smoking cessation medications, have had suboptimal impact due to barriers at the patient, practitioner and system level. This study explored the feasibility of a web-assisted tobacco intervention offering free prescription smoking cessation medication by mail if the smoker visited a physician for authorization. METHODS Adult Ontarians, smoking...