The effective life-time of new antimicrobials until the appearance first resistant strains is steadily decreasing, which discourages incentives for commercialization required clinical translation and application. Therefore, development should not only focus on better killing antimicrobial-resistant strains, but as a paradigm shift developing that prevent induction resistance. Heterofunctionaliz...

A new synergistic nanoparticle green synthesis from Vancomycin and CuoNPs techniques evaluation effect invite anti- bacteria resistance methicillin-resistant S. aureus with zone of inhibition reached 20mm characterization included UV-Visible, TEM , SEM X-ray. rating at various concentrations (512, 256,128,64,32 16) μg/ml. The (CuoNPs) are minimal toxicity, biology safety antibacterial.the wound...

We report findings from our investigation of the world's second clinical isolate of vancomycin-resistant Staphylococcus aureus (VRSA). An elderly man was hospitalized with an infected chronic heel ulcer and osteomyelitis. Before hospital admission, he received multiple courses of antibiotic therapy but, notably, no vancomycin. Numerous cultures of ulcer specimens (performed on an outpatient bas...

OBJECTIVES With the increase in nosocomial infections caused by coagulase negative staphylococci (CNS), laboratory diagnosis of CNS with reduced susceptibility to glycopeptides (vancomycin and teicoplanin) has become important. This study was designed to determine the glycopeptide susceptibility of clinical isolates of methicillin resistant coagulase negative staphylococci (MRCNS) at the depart...

Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the methicillin-resistance determinant of staphylococci, and is active against methicillin- and vancomycin-resistant Staphylococcus aureus. Ceftobiprole was compared to vancomycin in a rabbit model of methicillin-resistant S. aureus aortic valve endocarditis. Ceftobiprole and vancomycin were equally ef...

The first S. aureus strain with a vancomycin MIC 8 mg/L was isolated in 1996 from a Japanese patient to whom vancomycin therapy was ineffective [1]. Subsequently, dozens of VRSA strains were isolated from USA, France, Korea, South Africa, Scotland and Brazil [2], indicating that the issue is a global one [3]. However, the real essence of the issue lies in the latent dissemination of «hetero-VRS...

Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...

 Abstract Background: Inappropriate prescription of vancomycin has been shown to be asso- ciated with induction of antibiotic resistance. The objective of this study was to deter- mine the incidence of inappropriate use of vancomycin in a tertiary care hospital in Iran. Methods: A descriptive cross-sectional investigation was performed from September 2004 to March 2005 in all units of a general...