BACKGROUND AND AIM OF THE STUDY A study was conducted to measure in vitro the procoagulant properties of platelets induced by flow through mechanical heart valves. METHODS The procoagulant activity of platelets was measured using a real-time assay of platelet activation state (PAS), which was based on a modification of the prothrombinase method. Acetylated prothrombin was used instead of norm...

Picoliter drops made in microfluidic devices can serve as individual compartments for chemical reactions and can be processed at kilohertz rates with high precision. This combination of speed and containment is very useful for highthroughput screening, for discovering novel drugs, for sorting analytes and worms, and for directed evolution of enzymes and cells. For applications in microfluidics,...

Engine performance depends on two main factors of engine speed and ignition time. Ignition timing can affect engine life, fuel economy and engine power. In this paper, to study engine performance of Peugeot 206 TU3A with comparison ratio of 10.5:1 and displacement of 1361CC in MATLAB software, a two-zone burned/unburned model with the fuel burning rate described by aWiebe function was used for ...

Posterior urethral valve and vesical calculus are individually among the most common causes of obstructive lower urinary complaints in children. There are very few reports of association between posterior urethral valves and bladder calculus. We report three such cases. This association of the vesical calculi with posterior urethral valves may lead to a delay in the diagnosis of the posterior u...

Whether antithrombotic therapy in elderly patients differs from that in younger populations depends on whether the risk for such bleeding differs in the elderly. Regarding long-term therapy with warfarin derivatives, evidence shows that there is a difference. The anticoagulation response to warfarin is exaggerated with advancing age. This article discusses antithrombotic therapies for valvular ...

Amyloid associated with seven sclerotic and two normal aortic and mitral valves was studied. The sclerotic valve amyloid contained microfibrils with typical random orientation and a fibril width of 9.5-12.5 nm. The amyloid deposits demonstrated permanganate-resistant Congophilia and contained the amino acid tryptophan. Immunofluorescence studies showed P-component in amyloid deposits of 6 of 7 ...

Prosthetic valves have revolutionized the way we treat patients with valvular disease. Before the advent of these valves patient’s options were limited and morbidity and mortality high. In the early 1960’s valve replacement surgery was introduced which dramatically changed the management of these patients. Prosthetic valve technology continues to evolve and surgeons have multiple options to off...

Fluidic larger-scale integration (LSI) resides at the heart of comprehensive sample-to-answer automation and parallelization assay panels for frequent ubiquitous bioanalytical testing in decentralized point-of-use/point-of-care settings. This paper develops a novel “digital twin” strategy with an emphasis on rotational, centrifugo-pneumatic flow control. The underlying model systematically conn...