نتایج جستجو برای: value based tam
تعداد نتایج: 3472403 فیلتر نتایج به سال:
A putative relationship between growth impairment of Bacillus stearothermophilus by tamoxifen (TAM) and TAM-induced perturbation of the physical properties of bacterial membrane lipids has been observed. The supplementation of the growth medium with Ca2+ (a membrane stabilizer) partially relieves growth inhibition by TAM, allowing growth at TAM concentrations that fully impair growth in the bas...
Purpose: Tamoxifen (Tam) is the most prescribed hormonal agent for treatment of estrogen receptor a (ERa)-positive breast cancer patients. Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy had elevated levels of Dicer. Experimental Design: We overexpressed Dicer in ERa-positive MCF-7 human breast cancer cells and observed a concomitant increase in exp...
Gliomas are the most common and aggressive of brain tumors in adults. Cancer stem cells (CSC) contribute to chemoresistance in many solid tumors including gliomas. The function of prostate apoptosis response-4 (Par-4) as a pro-apoptotic protein is well documented in many cancers; however, its role in CSC remains obscure. In this study, we aimed to explore the role of Par-4 in drug-induced cytot...
S U M M A R Y In this study, based on a 2-D thermomechanical finite element model, the uplift of the Transantarctic Mountains (TAM) is discussed in relation to the flexural uplift of a rheologically layered lithosphere, which is described by Vening-Meinesz’s cantilever kinematics. The general model behaviour shows that the thickness of the crust and the geothermal gradient in the lithosphere ar...
Purpose This paper aims to empirically compare the degree which two technological interventions, based on computer-supported collaborative learning (CSCL) and technology acceptance model (TAM), were associated with a different incidence of financial biases. Design/methodology/approach The study adopted quasi-experimental research design. authors randomly assigned participants (N = 507) one trai...
The Technology Acceptance Model (TAM) and Theory of Planned Behavior (TPB) are widely used in the information systems (IS) literature to explain and predict user technology acceptance behavior. Although these models have been utilized separately in the earlier studies, to increase the richness and predictive power of their studies, scholars have combined both theories in more recent studies. Ho...
Twenty percent to 30% of transient abnormal myelopoiesis (TAM) observed in newborns with Down syndrome (DS) develop myeloid leukemia of DS (ML-DS). Most cases of TAM carry somatic GATA1 mutations resulting in the exclusive expression of a truncated protein (GATA1s). However, there are no reports on the expression levels of GATA1s in TAM blasts, and the risk factors for the progression to ML-DS ...
When a figure discretely and instantaneously changes its shape, observers typically do not perceive the abrupt transition between shapes that in fact occurs. Rather, a continuous shape change is perceived. Although this illusory ‘‘transformational apparent motion’’ (TAM) is a faulty construction of the visual system, it is not arbitrary. From the many possible shape changes that could have been...
Receptor tyrosine kinases, Tyro-3, Axl and Mer, collectively designated as TAM, are involved in the clearance of apoptotic cells. TAM ligands, Gas6 and Protein S, bind to the surfaces of apoptotic cells, and at the same time, interact directly with TAM expressed on phagocytes, impacting the engulfment and clearance of apoptotic cells and debris. The well-tuned and balanced actions of TAM may af...
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