sodium valproate and its derivatives have been widely used for anticonvulsant treatment since the 1970s, but in the past decades, due to its pharmacological and biological features, it has been well used in treatment of various psychiatric disorders, such as mood disorders and substance use disorders. sodium valproate is quickly absorbed in about 1-2 hours after oral taking and maximum plasma c...

A 21-year-old male known case of primary hypothyroidism, Seizure disorder sequelae of an old trauma receiving sodium valproate, clobazam and phenobarbitone for control of Generalized tonic clonic seizures reported to neurology OPD with history of altered sensorium and gait unsteadiness for 1 week with history of hike in valproate dose 2 weeks before. On examination he was drowsy. Neurological e...

introduction: sodium valproate is an anti convulsant drug which has been used to treat epileptic patients for last decades. even a pregnant patient has to use this drug for the treatment of epileptic seizure. the purpose of this investigation is to study the effect of this medicine on the embryo in the mouse. materials and methods: eight pregnant mice were given 200 mg/kg (i.p.) of sodium valpr...

BACKGROUND The hyperfunction and activation of platelets have been strongly implicated in the development and recurrence of arterial occlusive disease, and various antiplatelet drugs are used to treat and prevent such diseases. New antiplatelet drugs and many other drugs have been developed, but some drugs may have adverse effects on platelet functions. OBJECTIVE The aim of this study was to ...

An unselected series is presented of 17 infants born to epileptic mothers and exposed to sodium valproate during pregnancy. Nine infants had minor abnormalities and of these infants five also had major malformations, described as the 'fetal valproate syndrome'. The most frequent malformation was congenital heart disease. Nine of the infants had manifestations of withdrawal, such as irritability...

Sodium valproate is a broad-spectrum anticonvulsant drug that has been on the UK market since 1973​[1]​. In UK, it licensed for treatment of epilepsy and bipolar disorder can also be considered in patients with episodic or chronic migraine​[2]​. Commonly used brands include Dyzantil (Aspire Pharma), Epilim (Sanofi), Episenta […]