AIMS Overexpression of c-myc protein has independent prognostic significance in a variety of primary and metastatic cutaneous melanomas which suggests a possible role for this gene in melanomagenesis. We have therefore examined the importance of this oncogene in uveal melanoma and studied the coexpression of two other gene products, Bcl-2 and p53, which might contribute to its effect. METHODS...

A 45-year-old man with primary systemic amyloidosis was found to have bilateral uveal effusions secondary to thickened sclera according to magnetic resonance imaging of the orbits. The patient was treated with bilateral sclerectomies and vortex vein decompression, and had an excellent outcome. Light microscopy of excised sclera revealed severe infiltration of the tissue by amyloid. To our knowl...

E/xtensive investigation of the uveal circulation and ocular blood flow has been carried out since the original work by Waller in 1856. A dynamic determination of the uveal blood flow without alteration of normal physiologic processes has been hampered by the complexity of the vascular supply and its inaccessibility. Several recent reviews" have summarized previous methods used. The significanc...

Melanoma of the uveal tract is a life-threatening tumor that also presents a major threat to the function of the eye. Although the disease accounts for few cancer deaths in the United States each year, approximately one quarter of affected patients eventually die from metastasis. This number is greater in patients with certain characteristics that are associated with poor prognosis. The annual ...

2014 Increased knowledge of the role that dysregulated MAPK signaling plays in melanoma has opened the door for novel therapeutic strategies, among them MEK-targeted approaches. With the recent approval of the selective MEK inhibitor trametinib, both as a single agent and in combination with dabrafenib for patients with BRAF-mutant metastatic melanoma, MEK-based therapy now has a place as a sta...

Aqueous extract of C. longa when administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade and aqueous humor (AH) protein level compared to vehicle treated group. Although, prednisolone group showed significantly lower clinical grade, histopathologica...

Nanophthalmos, uveal effusion syndrome, and acute angle closure glaucoma (ACG) can present as a continuum in a patient, as is described here. This patient's angle closure was thought to be caused by idiopathic uveal effusion syndrome, and while there are no generally accepted diagnosis criteria for nanophthalmos, our patient fulfilled the criteria as defined by Wu.10 To prevent development of f...

Breast cancer is one of the most common malignant diseases occurring in women, and its incidence increases over the years. It is the main site of origin in ocular metastatic disease in women, and, due to its hematogenous nature of metastatic spread, it affects mainly the uveal tissue. The purpose of this paper is to summarize the clinical manifestations of the breast cancer ocular metastatic di...

BACKGROUND Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive disease in its metastatic scenario, and the new armament like targeted and immunotherapies are sti...

Zeaxanthin at nonlethal dosages (3-10 μM) significantly inhibited the cell migration of cultured uveal melanoma cells (C918 cell line) as determined by wound healing assay and Boyden chamber assay. Matrigel invasion assay showed that cell invasion of uveal melanoma cells could be significantly inhibited by zeaxanthin. Secretion of MMP-2 by melanoma cells was significantly inhibited by zeaxanthi...