Pregnant ewes and their fetuses were instrumented between 110 to 120 days of gestation (term, 145 days) for monitoring heart rate, blood pressure, uterine artery blood flow, and fetal intra-abdominal umbilical artery blood flow and arterial blood gases. DOM (2,5-dimethoxy-4methyl-amphetamine) was administered intravenously to the ewe in doses of 1, 2.5, 5, 10, or 20 fig/kg. Maternal administrat...

Objective. To examine the value of one-step uterine artery Doppler at 20 weeks of gestation in the prediction pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR). Methods. A prospective multicentre study that included all women with singleton pregnancies at 19-22 weeks of gestation (w). The mean pulsatility index (mPI) of both uterine arteries was calculated. Receiver-operating cha...

Uterine artery blood flow (UABF) is critical to maintaining uterine perfusion in nonpregnant states and for uteroplacental delivery of nutrients and oxygen to the fetus during pregnancy. Impaired UABF is implicated in infertility and several pregnancy complications including fetal growth restriction, small for gestational age, and preeclampsia. The etiology of abnormal UABF is not known. Here, ...

Uterine artery embolization (UAE) is an established, organ-preserving, safe and effective procedure in the therapeutic spectrum treatment of fibroid-related symptoms. The aim of UAE is the reduction or elimination of fibroid-related symptoms, but not the removal of the myoma. However, it also accomplishes a reduction of the size of the fibroid. There is a consensus between the disciplines of gy...

We have studied the effects of crystalloid (Ringer's acetate 1 litre) preloading and subsequent spinal anaesthesia in 12 pre-eclamptic parturient patients undergoing elective Caesarean section. Maternal placental uterine artery circulation was measured using a pulsed colour Doppler technique with simultaneous measurement of maternal haemodynamic state. Despite preloading, mean maternal systolic...

OBJECTIVES To evaluate whether the measurement of maternal serum inhibin A, activin A and placental growth factor (PlGF) at 12 + 0 to 16 + 0 weeks of gestation alone or in combination with second-trimester uterine artery Doppler pulsatility index (PI) is useful in predicting pre-eclampsia. METHODS This was a case-control study of pre-eclampsia. From pregnant women attending their first antena...

Obstetric vasculopathies are a set of apparently heterogeneous and poorly understood conditions. Conditions like recurrent miscarriages due to fetal demise, pre-eclampsia, IUGR, recurrent still births and accidental hemorrhage all seem to have the same underlying etiopathology. They are grouped into one large set coined as ‘Obstetric Vasculopathies’. Resistance to blood flow in the uterine arte...