Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment. Urticarial testing including laboratory and in-office testing was all negative. The patient has prevented urticaria symptoms with ora...

On 25th November, 1939, one Dr. A received an injection of anti-tetanic serum 500 units, for a shoe-nail bite on his heel. Almost at once he developed the following symptoms and signs:? (1) Symptoms.?Severe constricting pain across the chest, inability to breathe properly and giddiness. _ (2) Signs.?Cyanosis of the face, urticarial eruptions all over the body and weak pulse leading to a complet...

Now and again one is faced with the problem of a case ofhaematuria whose cause thorough investigation fails to determine. Many such cases are termed 'essential haematuria', and almost every volume of the Quarterly Cumulative Index Medicus gives one or more references to papers about this mysterious condition. Below is an account of a child who had frequent attacks of haematuria immediately foll...

Oral anticoagulants are associated with several adverse skin manifestations ranging from ecchymosis, purpura, and hemorrhagic necrosis to maculopapular rash, vesicular urticarial eruptions and purple toes. Skin necrosis is a rare but serious side effect of warfarin therapy, associated with significant morbidity and mortality. The prevalence of warfarin induced skin necrosis (WISN) is 0.01-0.1%....

We describe a 14-month-old girl who initially presented with 8 days of fever, conjunctival injection, rash, and irritability, admitted with a presumptive diagnosis of Kawasaki disease. Further history revealed intermittent urticarial-like rash since 3 months of age and pathological evaluation showed a perivascular infiltrate of neutrophils and lymphocytes. Here, we discuss the key points surrou...

Materials and methods Prospective, randomized clinical trial was carried out in a teaching hospital. All patients were asked to evaluate the severity of pruritus on urticarial activity score (UAS). Patients were then given oral prednisolone 30 mg for 5 days and tablet levocetirizine 5 mg twice daily for 6 weeks and only levocetirizine tablet 5 mg twice daily for 6 weeks. Patients’ conditions we...

Pruritic urticarial papules and plaques of pregnancy is considered the most common pruritic skin condition seen in pregnancy, and its classic presentation and treatment options have been well described. However, the exact etiologic factor of this condition remains obscure. This article presents an unusual case to demonstrate a variation in presentation of this disease as well as a unique course...

Introduction Mutations in the NLRP3 gene are associated with the dominantly inherited cryopyrin-associated periodic syndrome (CAPS) characterized by episodes of fever, urticarial rash, arthralgia, myalgia, eye inflammation, and, in its more severe forms, bony abnormalities and CNS inflammation. Of the 145 sequence variants in NLRP3 reported to date, 30 are either nonpathogenic or of undetermine...