نتایج جستجو برای: urokinase plasminogen activator
تعداد نتایج: 53622 فیلتر نتایج به سال:
Plasminogen activator inhibitor-2 (PAI-2) is well documented as an inhibitor of the extracellular serine proteinase urokinase-type plasminogen activator (uPA) and is expressed in activated monocytes and macrophages, differentiating keratinocytes, and many tumors. Here we show that PAI-2 has a novel intracellular function as a retinoblastoma protein (Rb)-binding protein. PAI-2 colocalized with R...
Tranexamic acid (TXA) has anti-plasmin activity and been shown when administered orally to be effective against melasma, for which it is considered first-line pharmacotherapy. Several studies have that topically applied TXA also melasma skin hyperpigmentation caused by sunburn inflammation. The concentration in the epidermis dermis/vasculature estimated from its distribution after closed applic...
Several cell biological studies have shown that the invasiveness of a variety of tumors depend on the regulated expression of proteolytic enzymes that degrade the surrounding extracellular matrix and dissociate cell-cell and/or cell-matrix attachments. One such enzyme, the serine protease urokinase-type plasminogen activator (uPA), converts enzymatically inactive plasminogen into the widely act...
The fibrinolytic characteristics of the endothelial hybrid cell line EA.hy 926, established by fusing a human umbilical vein endothelial cell with a human carcinoma cell line, were studied. The hybrid cell line produced large amounts of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1, and a small amount of urokinase. All plasminogen activator present in conditio...
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