PURPOSE MicroRNAs are small noncoding RNAs and microRNA-214 (miR-214) has been associated with the inhibition of cancer cell growth, migration, and invasion. The aim of this study was to investigate whether cell-free miR-214 isolated from urine could be used as a biomarker for non-muscle-invasive bladder cancer (NMIBC). MATERIALS AND METHODS A total of 138 patients with primary NMIBC and 144 ...

BACKGROUND A study was undertaken to determine the relation between urinary cadmium levels and lung function in a nationally representative cohort of current, former, and never smokers in the US. Urinary cadmium levels reflect the total body burden of cadmium. METHODS The following data from the Third National Health and Nutrition Examination Survey were analysed: urinary cadmium (adjusted fo...

Background: A study was undertaken to determine the relation between urinary cadmium levels and lung function in a nationally representative cohort of current, former, and never smokers in the US. Urinary cadmium levels reflect the total body burden of cadmium. Methods: The following data from the Third National Health and Nutrition Examination Survey were analysed: urinary cadmium (adjusted fo...

Fibroblast-specific protein 1 (FSP1)-expressing cells accumulate in damaged kidneys, but whether urinary FSP1 could serve as a biomarker of active renal injury is unknown. We measured urinary FSP1 in 147 patients with various types of glomerular disease using ELISA. Patients with crescentic GN, with or without antinuclear cytoplasmic antibody-associated GN, exhibited elevated levels of urinary ...

Introduction: Kerman province was one of the Iran regions with endemic goiter. Following initiation of the program of iodine deficiency control in 1989, production, distribution and consumption of iodized salt were begun. This study was done in 2001, as part of the national monitoring survey, in Kerman. Method: In this study, 1200 schoolchildren, aged 7-10 years (600 boys & 600 girls), were sel...

OBJECTIVES We investigated the relationship between the urinary levels of biopyrrins and the severity of heart failure (HF). BACKGROUND Oxidative stress is evident in heart disease and contributes to the development of ventricular dysfunction in patients with HF. Biopyrrins, oxidative metabolites of bilirubin, have been discovered as potential markers of oxidative stress. METHODS We measure...

OBJECTIVE Interstitial cystitis/bladder pain syndrome (IC/BPS) is considered a bladder disorder due to localized chronic inflammation. This study investigated the nerve growth factor (NGF) levels in serum and urine in patients with IC/BPS. MATERIALS AND METHODS Thirty patients with IC/BPS and 28 normal subjects without lower urinary tract symptoms were recruited from an outpatient clinic. IC/...

Non-muscle-invasive bladder cancer (NMIBC) is one of the most common malignant tumors in the urological system with a high risk of recurrence, and effective non-invasive biomarkers for NMIBC relapse are still needed. The human urinary proteome can reflect the status of the microenvironment of the urinary system and is an ideal source for clinical diagnosis of urinary system diseases. Our previo...

l-fucose (6.deoxy. l.galactose) is the only monosacharide which is placed in non reducting position of glycoproteins structure in l-deoxy form. l-fucosidase and fucosy 1 transferase directly take part in the elevation or decrease of sorum l-fucose levels. tumors may directly induce enzymes that release l-fucose from glycoproteins formed in the neoplastic tissue, or the glycoproteins may be rele...